Effects of chronic ingestion of Bisphenol A on gut contractility in rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 10
Abstract
Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development. Despite the fact that the gastrointestinal tract is chronically exposed to food containing BPA, its effect on the gut motility is poorly understood. Aims and Objectives: The present study attempted to assess the small and large gut contractility in vitro in male rats fed with BPA-mixed food for 28 days. Materials and Methods: This study was carried out in 8 adult male albino rats of 150-200 g weight. One group (4 rats) was subjected to daily oral administration of BPA (50 µg/kg/day) for 28 days. Another group of 4 rats was Sham-fed and served as control. With the help of organ bath preparations and computerized data acquisition system, in vitro isometric contraction (spontaneous and agonist-induced) was recorded from small gut (distal ileum) and large gut (mid colon) segments. Results: Recordings of spontaneous contractions revealed significantly (P < 0.05) decreased contractile tension in small gut and a decrease in both tension and frequency in large gut of the BPA-fed group of rats. Conclusion: Chronic exposure of BPA depresses spontaneous and agonist-induced contractility of small and large gut of rats.
Authors and Affiliations
Devarshi Dixit, Sanjeev K Singh, Anil Kumar Tiwari, Maloy B Mandal
Keywords
Related Articles
- EP ID EP291992
- DOI 10.5455/njppp.2017.7.0518906062017
- Views 63
- Downloads 0
A comparative analysis of cardiovascular response to stress in menstrual and follicular phase in medical students
Background: Autonomic function tests based on cardiovascular responses to stressors are simple and non-invasive methods to help the clinician to make a proper assessment of the state of autonomic nervous system so as to...
Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial
Background: Musculoskeletal diseases with painful reflex muscle spasm have a high prevalence. Because of reflex muscle spasm, muscle relaxants are frequently used either alone or in combination with analgesics. Eperisone...
Randomized prospective double-blind comparative clinical study of ebastine and its combined preparation of montelukast in persistent allergic rhinitis
Background: Antiallergic drugs are widely prescribed in allergic rhinitis (AR). Antihistamines and antileukotrienes are effective only in providing symptomatic relief of allergic symptoms, often used as fixed dose combin...
Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study
Background: Chemotherapy-induced thrombocytopenia (CIT) is a detrimental side effect of cancer chemotherapy. Several pharmacologic agents have been evaluated, but their thrombopoietic activity is modest and often associa...
Evaluation of vascular function in depigmented black women: Comparative study
Background: Prolonged application of skin depigmenting substances could expose human organism to serious general complications such as hypertension or diabetes. Artificial depigmentation (AD) is a widespread practice wit...