Effects Of Curcumın, Sulforaphane And Intralıpıd İn The Management Of Organophosphate Toxİcİty
Journal Title: International Journal of Current Medical and Biological Sciences - Year 2021, Vol 1, Issue 2
Abstract
Background:Organophosphates (OP) are a group of chemical agents with frequent exposure due to accidents, suicide attempts or occupational reasons consisting of agricultural and industrial usage. The aim of the present study is to examine the influence of curcumin (CUR), sulforaphane (SFN) and intralipid treatments with known antioxidant effects in OP poisoning.Material and method:In the experimental study, an OP toxicity model was createdby administering a dose of 30 mg / kg p.o malathion (MAL) to 30 rats divided into five equal groups, excluding the control group. Electrocardiography (ECG) and electromyography (EMG) examinations were performed on all rats at the 2nd and 12th hours and CUR, SFN and intralipid were administered in certain doses to rats other than the control group. In the liver and kidney tissue samples taken after the rats were sacrificed at the 24th hour; Superoxide Dismutase (SOD), Active Glutathione (GSH), Malondialdehyde (MDA) levels were assessed, whereas in the serum; Alanine aminotransferase (ALT), Aspartate transaminase (AST), urea, creatinine and pseudocholinesterase (PChE) levels were studied.Results:PChE levels of the rats were significantly lower in the OP group, and ALT and AST levels were significantly higher. There was no significant difference in the levels of SOD, MDA and GSH. ECG and EMG results were evaluated as normal in all groups.Conclusion:the present study, it is thought that CUR may have a therapeutic effect on liver tissues in OP toxicity, while SFN and intralipid may be effective in liver tissues by showing antioxidant properties and reducing organophosphate-inducedpseudocholinesterease suppression, respectively. Additionally, it is suggested that ECG and EMG alone are not sufficient in evaluating cardiotoxicity and neurotoxicity in the acute period.
Authors and Affiliations
Aslı Yasemen Savaş, Serkan Gürgül , Doç. Dr. Nurşah Başol
Keywords
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