Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
The present study was designed to elucidate the antioxidant effect of (-)-epicatechin in streptozotocin (STZ)-induced diabetes in rats. Intraperitoneal administration of (-)-epicatechin at doses of 15 and 30 mg/kg to diabetic rats for a period of 35 days resulted in a significant decrease in blood glucose, thiobarbituric acid reactive substances and hydroperoxides and a significant increase in the concentration of glutathione and the activities of catalase, superoxide dismutase and glutathione peroxidase. (-)-Epicatechin at a dose of 30 mg/kg was found to be more effective. Administration of insulin to diabetic rats normalized the changes caused by STZ.
Authors and Affiliations
Sabarimuthu Quine, Pamakanthan Raghu
Keywords
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