Effects of Hydro-Alcoholic Leaf Extract of Kardeh (Biarum Bovei Blume) on the Blood Glucose and Lipid Peroxidation in Cerebral Tissues and Lipid Profile in Streptozotocin Induced Diabetic Rats
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2016, Vol 8, Issue 1
Abstract
Objective: Oxidative stress is the result of an imbalance between free radical production and antioxidant defenses of the body. The use of antioxidants can have preventive effects in diabetes. The present study aims to show the effects of Biarum Bovei extracts on lipid profile, lipid peroxidation in streptozocin induced diabetic male rats. Materials and Methods: Animals were randomly assigned to the control group, diabetic with streptozotocin (STZ 60 mg/kg) and 5 diabetic groups rats which have received hydro-alcoholic extract Biarum Bovei (50, 100, 200, 400, 800 mg/kg) via gavages for two weeks. Blood glucose, serum lipid profile and malondialdehyde (MDA) in brain tissue were measured at the end of experiment. Results: The results indicate that blood glucose in diabetic group increased significantly (P<0.0001) in comparison with the control group. Biarum Bovei extract at a dose (100 and 200 mg/kg), causing a significant decrease in blood glucose levels (P<0.01). The MDA significantly decreased in the hippocampus in the group receiving 100, 200 mg/kg Biarum Bovei extract (P<0.001, P<0.01) respectively. Conclusion: Hydro-alcoholic extract of Biarum Bovei may have antioxidant properties which reduce blood glucose and complications of diabetes such as lipid peroxidation and lipid profiles. It can be used from this plant to improve diabetes along with medication
Authors and Affiliations
Zohre Valizadeh, Maryam Rafieirad
Keywords
Related Articles
- EP ID EP636334
- DOI -
- Views 46
- Downloads 0
Effects of High Intensity Interval Training and Combined Training on Serum Apelin Levels and pancreatic β-cell function in Overweight Type 2 Diabetes Women
Objective: Physical exercise is a well-established therapeutic method in type 2 diabetes treatment. The purpose of this study was to investigate the effects of eight weeks combined and High Intensity Interval Training on...
Positive Psychotherapy Effect on Life Expectancy and General Health of Type 2 Diabetic Patients: A Randomized Controlled Trial
Objective: Diabetes is a chronic disease that influences mental and physical health. Regarding the importance of diabetic patients’ psychological status, this research studied the effect of group positive psychotherapy o...
Remote Ischemic Preconditioning and Diabetic Macular Edema
Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through v...
Evaluation of Fasting Blood Sugar via Salivary Glucose in Type 2 Diabetes Mellitus
Objective: Diabetes mellitus (DM) as an ongoing metabolic disorder worldwide is a major public health concern. Diagnosis of DM is depended on clinical symptoms and laboratory findings. Fasting blood glucose (FBG) monitor...
Implementation of "Chronic Care Model" for Diabetes Care in Iranian Primary Health Care: Does it work?
Objective: Traditional health care systems were not capable to face successfully with chronic diseases including diabetes mellitus. In this regard, the Chronic Care Model or CCM was created to promote quality of care. Th...