Effects of Intra-Articular Platelet-Rich Plasma Administration in Temporomandibular Joint Arthritis: An Experimental Study
Journal Title: Meandros Medical and Dental Journal - Year 2018, Vol 19, Issue 3
Abstract
Objective: Osteoarthritis is defined as a disease that begins with focal and progressive destruction in articular cartilage with biomechanical, biochemical, inflammatory and immunologic reactions and may cause pathologic changes in the subchondral bone and joints. The platelet-rich plasma accelerates wound and bone healing in clinical trials; decreases swelling, pain, infection and scarring; and controls bleeding. In this study, we studied the effect of intraarticular thrombocyte-rich plasma administration in the model of temporomandibular osteoarthritis induced by monosodium iodoacetate (MAI) injection. Materials and Methods: Forty-five Wistar male rats were used in the study. The rats were divided into 3 groups, each containing eight animals. In the first group, only serum physiologic injections were performed to the temporomandibular joints and identified as the control group. In the second group, arthritis model was created by injecting MAI to the temporomandibular joint. Third group was the study group intraarticular platelet rich plasma injections were performed 4 weeks after monosodium iodoacetate injections. Results: When cartilage thicknesses were evaluated, there was a significant decrease in group 3 arthritis when compared with other groups. In the study group, cartilage thickness was not significantly different from control groups, but statistically significant improvement was observed when compared to monosodium idoacetate group. Although subchondral cyst formations were also observed in the study group a statistically significant difference was observed between the arthritis group. Conclusion: We believe that our study results support, and enlightens therapeutic effects of platelet rich plasma on temporomandibular joint arthritis.
Authors and Affiliations
Heval Selman Özkan, Saime İrkören, Huray Karaca, Taha Deniz Yıldırım, Kadir Çiçek, Canten Tataroğlu
Keywords
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- EP ID EP399339
- DOI 10.4274/meandros.29484
- Views 117
- Downloads 0
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