Effects of Leptin, Resistin, and PPAR-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population
Journal Title: Journal of Academic Research in Medicine - Year 2020, Vol 10, Issue 2
Abstract
Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years. There are many candidate genes related to the genetic infrastructure of ACS and obesity. This study aimed to investigate the association of Leptin glutamine to arginine substitution (Gln223Arg), Resistin-420 Cytosine/Guanine (C/G), and proliferator-activated receptor-gamma (PPAR-γ) proline to alanine substitution (Pro12Ala) polymorphisms in obese patients with ACS in the Turkish population. Methods: Fifty obese patients concurrently diagnosed with ACS and 42 healthy controls were included in this study. These polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis methods. Results: The PPAR-γ Pro12Ala polymorphism Pro/Ala genotype (p=0.001) was found to be higher in the obese patients with ACS, while the (Proline/Proline) genotype (p=0.001) was significantly higher in the control group. The GC genotype (p=0.045) distribution of Resistin-420 C/G was found to be significantly higher in the controls compared to the patient group. Conclusion: Our study presents new findings that the PPAR-γ Pro12Ala polymorphism Pro/Ala genotype is a risk factor for ACS in obese individuals, whereas Resistin-420 C/G polymorphism GC genotype and PPAR-γ Pro12Ala polymorphism Pro/Pro genotype may be protective factors for ACS in obese individuals.
Authors and Affiliations
Akif Arat, Ümit Yılmaz, Nesibe Yılmaz, Osman Fazlıoğulları, Faruk Çelik, Cem Başaran, Ümit Zeybek
Keywords
Related Articles
- EP ID EP688860
- DOI 10.4274/jarem.galenos.2020.2931
- Views 147
- Downloads 0
The Diagnostic Value of Free Androgen Index in Obese Adolescent Females with Idiopathic Hirsutism and Polycystic Ovary Syndrome
Objective: The free androgen index (FAI) is the ratio between total testosterone and sex hormone binding globulin (SHBG), and it has been proposed as a marker. FAI is increasingly used in the definitive diagnosis of pati...
Relationship Between Colon Wall Thickness in Computed Tomography Scan and Colon Cancer: A Retrospective Study
Objective: This study aimed to investigate the colonoscopic findings of patients with increased colonic wall thickness (ICWT) detected by abdominal computed tomography (CT) and to define the effectiveness of neutrophil/l...
Comparison of Feto-maternal Effects of Twin Pregnancies and Twin Pregnancies Caused By Assisted Reproductive Technology
Objective: Comparison of the effects of twin pregnancies using assisted reproductive technology (ART) and spontaneous twin pregnancies on maternal-fetal parameters. Methods: A total of 5,670 patients who were deliveried...
Assessment of Speech Intelligibility in Free-field Sound Chamber at Different Signal Noise Ratios
Objective: In the presence of background noise, understanding speech is challenging for any listener, especially for those with serious hearing loss. This study aimed to determine speech intelligibility of normal-hearing...
Anesthetic Approach for a Patient with 1q21.1 Microdeletion Syndrome: A Case Report
1q21.1 microdeletion syndrome is a chromosome abnormality where segment of genetic material on the long (q) arm of chromosome 1 at position 21.1 is missing or deleted. Distal 1q21.1 microdeletion is associated with micro...