Effects of Nigella Sativa Aqueous Extract on Serotonin (5-HT) Neurotransmitter: A Therapeutic Marker for Neurological Diseases and Related Disorder
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 3
Abstract
Abstract:Anxiety is a neuropathlogical condition which disturbs the normal routine life and CNS function. Serotonin is well known neurotransmitter responsible for pathogenesis of neurological diseases such as epilepsy, migraine, multiple sclerosis and Parkinson's disease &neuropsychiatric diseases like depression, anxiety and stress. Malfunctioning of 5-HT receptor, 5-HT transporter and mutation in gene code for its synthesis may contribute to abnormal function of serotonin. Nigella sativa is most common herb use as medicinal plant .In present investigation aqueous extract of Nigella sativa given to rats exerts anxiolytic and hyperserotonergic effect by increasing serotonin level in rat brain. Significant anixolytic effects were observed in open filed box and elevated plus maze. All these findings proved that Nigella sativa can be beneficial to treat neurological behavior defect which is due to hypoactivity of serotonergic neuron in brain. Keywords:Serotonin(5-HT),Tryptophan (Trp), Parkinson’s disease (PD), 5-hydroxyindoleacetic acid (5-HIAA), Selective serotonin reuptake inhibitors (SSRIs), Nigella sativa aqueous extract (NSAE). Open field box (OFB), elevated plus maze (EPM).
Authors and Affiliations
Farhat Bano, Naheed Akhter
Keywords
Related Articles
- EP ID EP397413
- DOI -
- Views 126
- Downloads 0
Clinical Profile of Deliberate Self Poisoning in Eastern Part of the Sri Lanka
Abstract:The rate of non-fatal deliberate self-harm (DSH) in Sri Lanka has increased in recent years, with associated morbidity and economic cost to the country. Pesticide ingestion is the commonest mode of suicide in As...
A Study on Repetitive Behavior in Different Childhood Disorders in A Tertiary Care Hospital
Abstract:Repetitive behavior is a common symptom in children and is characterised by sameness, rigidity and repetitiveness. These stereotypic and repetitive behaviors are seen in various psychiatric as well as neurologic...
Analytical Method Development and Validation of Metformin Hydrochloride and Benfotiamine in Bulk and Marketed Formulations
Abstract:In the present work, two simple and sensitive UV spectrophotometric methods have been developed for the quantitative estimation of Metformin Hydrochloride and Benfotiamine in combination using bulk and pharmaceu...
Formulation and Evaluation of Oxiconazole Nitrate Niosomal Gel for Transungual Delivery
Poor response of fungal nail infection to topical treatment with antimycosis is probably related to poor drug permeation into the infected nail. Niosomes are the nano carriers which play an increasingly important role in...
Outbreak of Cholera in Vea-Gunga, Bongo District of the Upper East Region, Ghana: Impact of Traditional Medicine and the National Health Insurance Scheme
Abstract: The financial cost of seeking formal health care is often the major barrier to accessing health care in poor countries. Consequently, the governments of several developing countries have introduced free health...