Effects Of Retinoic Acid On Survival Percent And Growth Of Swiss Albino Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
The development of an organism is a complex process of embryogenesis involved cell proliferation, differentiation, migration and organogenesis. Teratology is the branch of biology that deals with abnormal development . Many agents interfering the development process can cause malformations in the embryo. The study of these congenital abnormalities is called teratology and agents which are responsible for causing these malformations are called teratogens. Susceptibility to teratogens depends on the genotype of the organism, including species as well as strain differences. Etienne Geoffrey Saint Hilaire and his son in 1820 started experiments on chick embryo by disturbing its environment in different ways at different embryonic stages. They found some anomalies like Trioncephally, atrophy of eyes and spina bifida in his experiments (Tuli, 1968). In 1877 Dareste reported found some anomalies like Trioncephally, atrophy of eyes and spina bifida in his Experiments (Tuli, 1968). Retinoids are essential for spermatogenesis oogenesis, placental development, foetal morphogenesis and growth. The role of vitamin A in vision is well known . Active derivative of vitamin A (Retinoids ) play an important and multiple role in Mammalian development and homeostasis (Sapin, et.al. 1997, Dup et al 1997). These essential dietary compounds are needed in very small quantities, they are not synthesized by the animals and are obtained from external sources in the form of β carotene (C40H56). In cells of intestine β carotene is converted into vitamin A alcohol and is transported by blood to liver where it is esterfied and stored as vitamin A palmitate. RA is not stored in liver but is derived from retinal and it is biologically the most potent form of vitamin A.Vitamins are organic compounds which are devided into 2 categories i Fat soluble (A,D,E,K) And ii water soluble (B and C).Vitamin A belongs to fat soluble category of vitamins. A fat soluble substance essential for life was first discovered in egg yolk in 1909 by Stepp (Pawson, 1981; Robert and Sporn, 1984). It was confirmed by Mc Collum Devis in 1913 when he found a compound with similar biological activity in butter fats, egg yolk and cod liver oiland was named fat soluble vitamin A. In the present study effects of different doses on Survival rate on different development stages of Swiss albino mice are studied.
Authors and Affiliations
Dr Rashmi Sharma, Ashok Gupta
Keywords
Related Articles
- EP ID EP383468
- DOI 10.9790/3008-1102021216
- Views 71
- Downloads 0
Chemical Scheme of Water-Splitting Process during Photosynthesis by the Way of Experimental Analysis
Different water oxidation schemes during photosynthesis are developed from different view-point by analysis of different experimental data. In this paper, an approach will be done to create a symmetrical opinion among al...
Diversity of Butterflies at Tatapani Village, Balrampur District, Chhattisgarh, India
Butterflies are regarded as one of the prominent bio indicators of the environment and have the second largest number of scaly insects; therefore they must be conserved for the betterment of the health of the habitats. D...
Biosynthesis of silver nanoparticles using Streptomyces griseus PDS1 for anticancer activity
Biological synthesis of nanoparticles provides advancement over chemical and physical methods. The use of micro-organisms to synthesize functional nanoparticle has been of great innovative interest. The research work foc...
Morphological and Histological Effect of Oral Intake of Rose Water in Mouse
Rose water (Maa El-Ward) is one of the major products of rose, it is produced from the petals of Rosa damascene and contains about 0.08-0.12% of essential rose oil. Rose water is used widely between Saudi women (Saudi Ar...
Malaria parasitaemia and socioeconomic status of selected residents of Emohua community, Rivers State, Nigeria
:In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State...