Efficacy And Safety of Combination of Tamsulosin with Solifenacin And Tamsulosin Alone In Treatment of Double-J Stent Related Lower Urinary Tract Symptoms: A Randomized Clinical Trial
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Purpose: To compare the efficacy and safety of combination of Tamsulosin and Solifenacin with Tamsulosin alone in improving the lower urinary tract symptoms of patients with indwelling double-J ureteral stents (DJS). Materials and Methods: A total of 70 patients with DJS were randomly divided into 2 groups. In group I (𝑛 = 35), all patients received combination of both tamsulosin 0.4 mg and solifenacin 10 mg daily and in group II (𝑛 = 35) all patients received tamsulosin 0.4 mg daily. All patients completed the International Prostate Symptom Score (IPSS), quality of life component of the IPSS (IPSS/Qol) and Visual Analogue Pain Scale (VAPS) questionnaire, before insertion, at 3rd day of stenting and at 2 weeks after stenting. Urine for Routine and microscopic examination and culture and sensitivity were sent on 3rd postoperative day or before the discharge of patient and sexual discomfort was assessed after 2 weeks of stent insertion. Results: The demographics and preoperative questionnaires scores of both the groups were comparable. There were statistically significant differences in all scores in favor of groups I as compared to group II. Group I showed statistically significant differences in total IPSS with P value <0.001, QoL score with P value <0.001, and VAPS score with P value <0.001. Patients were also evaluated after 2 weeks for sexual discomfort and found 4 (15.4%) patients with tamsulosin and solifenacin had discomfort whereas 22 (84.6%) patients receiving tamsulosin had discomfort which was statistically significant (P value <0.001). Conclusions: Combined therapy of tamsulosin and solifenacin significantly alleviated lower urinary symptoms associated with double-J stents as compared to tamsulosin alone.
Authors and Affiliations
Shah Rs, Agrawal Cs, Singh Sk, Thapa N
Keywords
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- EP ID EP594771
- DOI 10.9790/0853-160406108116.
- Views 57
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