Efficacy of intravenous Dexmedetomidine in attenuation of hemodynamic response to laryngoscopy and endotracheal intubation
Journal Title: Asian Pacific Journal of Health Sciences - Year 2016, Vol 3, Issue 4
Abstract
Introduction: The process of laryngoscopy and endotracheal intubation are noxious stimuli and is associated with intense sympathetic activity which may precipitate intra-operative complications. Aim:To study the efficacy of intravenous dexmedetomidine in attenuation of hemodynamic response to laryngoscopy and endotracheal intubation. Materials and Methods: This was a prospective study conducted in a group of hundred patients. The study population was divided randomly into two groups.Group C – Control group (n=50) – received 10 ml of normal saline intravenously over 10 minutes, 10 minutes before induction and Group D – (n=50) – received Dexmedetomidine in the dose of 0.6 μg/kg body weight diluted in 10 ml of normal saline. Results: There was marked decrease in HR 10 minutes after Dexmedetomidine administration. HR, SBP, DBP and MAP markedly increased at 1 minute following laryngoscopy and intubation in the control group where as in Dexmedetomidine group there was a fall in HR, SBP, DBP and MAP at all times which was statistically significant. There was reduced thiopentone requirement and no increased sedation scoring in patients belonging to Dexmedetomidine group compared to control group. There were minimal side effects noted in the Dexmedetomidine group which were managed easily. Conclusion: Dexmedetomidine at a dose of 0.6μ/kg body weight given 10 minutes before induction significantly attenuated the hemodynamic response to laryngoscopy and tracheal intubation and there was reduction in dose requirement of thiopentone sodium without significant side effects
Authors and Affiliations
Dr. Kamalakar Karampudi
Keywords
Related Articles
- EP ID EP525257
- DOI 10.21276/apjhs.2016.3.4.37
- Views 153
- Downloads 0
The correlation between social support during the postpartum period and the level of readiness for hospital discharge
This is a descriptive study, aimed at determining the correlation between social support in the postpartum period and the level of readiness for hospital discharge. Methods: The study was conducted with 291 women during...
A study of management of recurrent dislocation of shoulder by arthroscopic bankart’s repair
Aim: Descriptive, Retrospective and Prospective study of surgical and functional outcome following, arthroscopic repair of the Bankart lesion of the shoulder with suture anchors. Materials and Methods: This is a study of...
Ultrasound guided Fine Needle Aspiration cytology of Hepatobiliary and Pancreatic lesions
Aim: To evaluate the reliability of ultrasound(USG) guided fine needle aspiration cytology(FNAC) in distinguishing between benign and malignant lesions of pancreas and hepatobiliary system and report the findings of sign...
Paravertebral block versus unilateral spinal anesthesia for inguinal hernia repair - A comparative clinical trial
Background: Inguinal hernia repair can be performed under satisfactory anesthetic conditions using general, regional, and peripheral nerve block anesthesia. Aims and Objectives: The aim of this study is to evaluate wheth...
Trend in pre eclampsia
Introduction: Pre eclampsia is a progressive disorder, in some circumstances; delivery is needed to halt the progression to the benefit of the mother and fetus. Aim: This study is designed to evaluate the incidence and e...