Efficacy of macular focal/grid laser photocoagulation with Ranibizumab for diabetic macular edema
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 11, Issue 6
Abstract
AIM: To investigate the effect of macular focal/grid laser photocoagulation with Ranibizumab on the treatment of diabetic macular edema(DME). <p>METHODS: Totally 70 patients(99 eyes)with DME treated in our hospital from August 2014 to August 2016 were randomly divided into the observation group and the control group, with 50 eyes and 49 eyes, respectively. Patients in control group were treated with macular focal/grid laser photocoagulation, and based on this, the observation group was treated with intravitreal injection of ranibizuma at 5-7d before operation. The best corrected visual acuity(BCVA)before and after operation was compared between the two groups. Central macular thickness(CMT)was examined by optical coherence tomography(OCT), and fluorescein fundus angiography(FFA)was used to examine the leakage area of retinal neovascularization(RNV)and macular edema. <p>RESULTS: The BCVA in both groups increased significantly after operation, and the BCVA in observation group was significantly higher than that of the control group at each time point after operation, the difference was statistically significant(<i>P</i><0.05). After treatment, the CMT and leakage area of RNV in both groups significantly decreased, and the leakage area of the observation group were significantly less than those in control group at each time point(<i>P</i><0.05). There were different degrees of macular edema leakage in the two groups before operation, and the proportion of eye with macular edema and leakage in observation group was significantly lower than that in control group, the difference was statistically significant(<i>P</i><0.05). No obvious complications occurred in the two groups. <p>CONCLUSION: Compared with macular focal/grid laser photocoagulation, the combination of macular focal/grid laser photocoagulation and ranibizumab has better curative effect on DME and RNV reduction. Moreover, the patients' visual acuity improve significantly with a higher safety.
Authors and Affiliations
Hong - Miao Ren
Keywords
Related Articles
- EP ID EP558524
- DOI 10.3980/j.issn.1672-5123.2018.6.24
- Views 121
- Downloads 0
Vision distribution and its influencing factors of two teenager aviation schools in Western China
AIM: To analyze the vision distribution and its related risk factors of two teenager aviation schools in Western China. <p>METHODS: The study was a cross-sectional survey. A total of 233 participants were randomly select...
Correlation analysis of BMP-6 and age-related neovascular macular degeneration
AIM: To investigate the correlations between aqueous concentrations of bone morphogenetic protein 6(BMP-6), interleukin 6(IL-6), and vascular endothelial growth factor(VEGF)and the parameters of macular edema acquired by...
Clinical efficacy of pseudo-ginseng powder for post-vitrectomy vitreous hemorrhage in diabetic patients
AIM: To evaluate the efficacy of pseudo-ginseng power for post-vitrectomy vitreous hemorrhage in diabetic patients and provide new insight into the treatment options. <p>METHODS: Totally 32 eyes of 32 patients with post-...
Optical coherence tomography in diagnosis of early primary open angle glaucoma
AIM: To evaluate the clinical value of retinal nerve fiber layer(RNFL)thickness, optic disc parameters and macular thickness by optical coherence tomography(OCT)in early diagnosis of primary open angle glaucoma(POAG). <p...
Activation of autophagy and paraptosis in rat retinal ganglion cells following acute intraocular hypertension
AIM: To study whether autophagy and paraptosis were activated in retinal ganglion cells(RGCs)after acute high intraocular pressure(IOP)in an experimental rat model and to explore the possible underlying mechanisms. <p>ME...