Efficacy of Prostate Specific Antigen as a Tumor Marker in Differentiating Prostatic Carcinoma from Other Prostatic Lesions
Journal Title: New Indian Journal of Surgery - Year 2018, Vol 9, Issue 1
Abstract
Prostate Specific Antigen has been widely used in diagnosis and management of patients with prostate cancer. It may be elevated in other prostatic diseases. The objective of this study was to evaluate its efficacy to diagnose and differentiate between benign and malignant enlargements. Study also determines relationship between serum prostate specific antigen levels and histopathologic findings in prostatic biopsies. Materials and Methods: Study was done at a tertiary care hospital in Telangana over 6 years. A total of 500 patients were included in the present study. Prior to surgery serum prostate specific antigen levels were determined for all the cases and the biopsies were sent for histopathology. Results: In the present study mean age of presentation was 64.24 years. Amongst the 500 cases, 451 (90.2%) were of Benign Prostatic Hyperplasia, 32 (6.4%) were of Prostatic Intraepithelial Neoplasia and 17 (3.4%) were of Prostatic Adenocarcinoma. Serum prostate specific antigen levels range distribution was considered into 3 groups as: 0-4 ng/ml included 404 (80.8%) cases, 5-9 ng/ml with 44 (8.8%) cases and 10 ng/ml included 52 (10.4%) cases. Present study revealed sensitivity 70%, specificity 91%, diagnostic accuracy 91%, positive predictive value 23%, and the negative predictive value 98%. Conclusion: PSA is specific for prostate but not for prostate cancer. PSA is raised in cancer, prostatic infection, urinary retention & Nodular Prostatic Hyperplasia. There is need of a more reliable and precise serum marker that reflects prostate cancer.
Authors and Affiliations
Gautam N. Gole
Keywords
Related Articles
- EP ID EP541887
- DOI 10.21088/nijs.0976.4747.9118.2
- Views 122
- Downloads 0
Outcome of Single Layer Gastrointestinal Anastomoses in Pediatric Age Group
Background and objectives: Many different techniques are currently used to join segments of the gastrointestinal tract following resection. This study is intended to study the feasibility of single layer technique in our...
Adult Female Lump Abdomen
Intussusception is commonly seen in pediatric age group and is rare in adults. Adults with intusussusception present with non specific symptoms and diagnosis is made by imaging. Most of the times the treatment requires r...
Correlation of Soluble CD73 Levels with Serum CRP and Creatinine Levels with Assessment of Mortality and Morbidity in Patients of Acute Pancreatitis
Background: Early assessment of disease severity and prediction of the course has been an important part of the initial resuscitation and management protocol in acute pancreatitis. Various markers for severity assessment...
Comparative Study of Fistula in ANO Management by Primary Closure and Open Wound Method
Introduction: Fistula in ano is one of the most common benign anorectal disorder associated with appreciable morbidity and inconvenience to the patient. The chronicity of its symptoms makes an otherwise healthy and activ...
Idiopathic Segmental Infarction of Omentum; Surgeon’s Perspective in Comparison with Conservative Line of Management
Segmental infarction of omentum was first described by Bush in 1896.Incidence is <.1% of laparotomies done for the a/c abdominal cases [5] .Incidence is more in males (2:1). Exact aetiology is not known so we take it as...