Efficacy of Single Application of Topical DoxycyclineHyclate and Triamcinolone Acetonide in Denture Adhesivein the Management of Recurrent Aphthous Stomatitis: AComparative Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Aim: To evaluate the efficacy of single application of topical doxycycline hyclateand single application of triamcinolone acetonide in the management of recurrent aphthousstomatitis for pain reduction. Materials and Methods: A total of 30 patients were selectedand divided into 2 groups( Group I and II) with 15 subjects belonging to each. Patients with aphthous ulcer were diagnosed on clinicalexamination and pain intensity wasmeasured using a discretevisual analog scale (VAS) of 0–10 (with 1 mm division, where “0” is no pain and “10” is worstpossible pain). Number of ulcers along withsize and duration of each ulcer were recorded. Group Iwas treated with doxycyclinehyclate(100mg)tablet crushed into fine powder and mixed with denture adhesive(fixon) and applied onto the lesion.Group II was treated with 0.1% triamcinolone acetonide gel mixed in denture adhesive and applied ontothe lesion. A pain scale sheet was given to each patient to self‑ evaluate the daily status of pain scale onthe day after treatment for about a week. Results:Pain intensity on VAS scale in Group I was 4.29 before treatment and 2.29 after treatment. Similarly,in Group II was 3.62 before treatment and 2.15 after treatment. Pain reduction in VAS‑ after treatment in 15Group I patients was 47 % after treatment on day 1. Moreover, in Group II was 41 % after treatment onday 1. Group I had faster ulcer healing 2.89 ± 0.745 days when compared to Group II 5.15 ± 0.917 dayswith the P value of (<0.001). Conclusion:Healing of the ulcer was significantly faster with doxycycline hyclatetreatment compared totriamcinolone ointment with no adverse effects. Doxycycline is proved to be one of the modalities for thetreatment of aphthous ulcer.
Authors and Affiliations
Gowharyaqub . , Zahoor Bhat, Bashir Wani, Gurvinder Kour, Rizwan Hamid
Keywords
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