Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 14, Issue 5
Abstract
Background: Transcatheter arterial chemoembolization (TACE) refractoriness is an indication for sorafenib treatment in patients with intermediate-stage hepatocellular carcinoma (HCC). This study aims at evaluating the efficacy of conversion of treatment to sorafenib on overall survival (OS) among trans arterial chemoembolization (TACE)-refractory HCC patients. Methods: This retrospective cohort study included 497 patients with HCC treated with TACE between January 2008 and December 2013 at the Kindai University Hospital. Among those patients, 56 were considered refractory to TACE. These TACE-refractory patients were grouped into two cohorts: a) patients who switched treatment from TACE to sorafenib (sorafenib group) and b) those who continued TACE (TACE group). We evaluated the OS of patients from the initial TACE.Results: Thirty-two patients were classified into the sorafenib group, while 24 patients were in the TACE group. The median OS from the initial TACE was 4.29 years in the sorafenib group and 2.14 years in the TACE group (p < 0.0010).Conclusion: Conversion of treatment to sorafenib might improve the OS in TACE-refractory patients with intermediate-stage HCC. Hence, conversion of treatment should be considered for HCC patients refractory to TACE.
Authors and Affiliations
Tadaaki Arizumic, Tomohiro Minami, Masatoshi Kudo
Keywords
Related Articles
- EP ID EP585992
- DOI 10.26717/BJSTR.2019.14.002610
- Views 166
- Downloads 0
The Laryngeal Mask Airway in Pediatric Anesthesia
Since the reports that the laryngeal airway mask (LMA) could be used safely and effectively in pediatric anaesthesia in 1990s [1,2], LMA are currently recommended for use in a variety of challenging scenarios, such as in...
How Does Stathmin Destabilize Microtubules?A Root of Consciousness and Alzheimer’s Disease
Alzheimer’s disease due to dementia and the memory brain that might be related to the microtubules disorder interrupt daily life. Alzheimer’s is a brain disease that causes a slow decline in concentrations, memory, think...
Yoga in Mental Health
Yogic techniques, such as asana and pranayama of Hatha Yoga, and various meditations, have been trailed through clinical and other scientific procedures. The results have established the preven...
Structure of Single Particles from Randomly Oriented Ensembles Using an X-Ray Free Electron Laser
The method of time-resolved crystallography offers a method of studying fast changes in structure during a chemical reaction. However, being a crystallographic method it is restricted to crystal structures. The problem w...
Aligning Pathology Assessment in a Learner-Cantered Undergraduate Medical Curriculum
Introduction: The Bond Medical Program delivers pathology in the preclinical years through interactive learning. Assessment for learning demandsfit-for-purpose assessmentthat aligns with the curriculum. In Year 2 of the...