Efficiency of Anti-Epileptic Drug Topiramate in Treatment of Glioblastoma: An InVitro Perception
Journal Title: Scholars Bulletin - Year 2018, Vol 4, Issue 5
Abstract
Abstract:Brain tumors account for 85% to 90% of CNS tumors. In 20-40% of the patients suffering from brain tumor (BT), seizures are common during the commencement of the disease. The relationship between the onset of seizures and brain tumor is poorly understood. These patients show a complex therapeutic profile making selection of the drugs very tough. The quality of life of the patient is highly compromised due to brain tumor-related epilepsy (BTRE) as it is drug-resistant and poses the challenging risk factor for everlasting disability. Hence, there arise the need of unique and multidisciplinary approach of proper selection of medications with minimum side effects. GlioblastomaMultiforme is a grade IV highly malignant tumor attacking the glia, which provides nourishment and assist in signal transmission. Glioma cells secrete glutamate and choose neurotransmitter receptors for their invasive growth. Glutamate binds to ionotropic receptors, activate calcium release mediating excitatory neurotransmission. The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission and are critical for spread of epileptic activity. Glutamate is the main culprit for both the occurrence of seizures and glioma metastases. Hence there lies an opportunity to use the anti-epileptic drugs which targets calcium permeable AMPA receptors for the treatment of glioblastoma as well as BTRE. Topiramate (TPM), a derivative of D-fructose is a novel broad spectrum anti-epileptic drug which shows antagonistic effect on AMPA receptor. When treated with TPM a dose-dependent decrease in live cell number, increase in the number of apoptotic cells, decrease in the calcium influx, reduction in phosphorylation of Akt, Erk1/2 expression were observed. Also phosphorylation of AMPA receptor in presence of EGF was observed. The data suggests that topiramate lead to decrease in proliferation and survival by decreasing calcium influx and inhibiting mitogenic and survival signalling in U87MG cells. Keywords:Brain tumors, AMPA receptors, neurotransmission.
Authors and Affiliations
Sharma Arpana, Kartha Anitha, Rana Pratap Singh, Mishra J. P. N
Keywords
Related Articles
- EP ID EP397189
- DOI -
- Views 135
- Downloads 0
Geological Characteristics and Development Characteristics of the 45 Block in Daqing Oilfield
Abstract: This paper introduces the geological features and the development of daqing oilfield, through the characteristics of reservoir classification and correlation and small layers evaluation, quantitative analysis o...
Sources of Kenyan Bill of Rights (Art. 32-34) and Media advocacy for the Rights and Freedoms Guaranteed in the Constitution
Abstract:This paper is an analysis of articles 32 (freedom of conscience, religion, belief and opinion), articles 33 (freedom of expression) and article 34 (freedom of media) under Chapter 4 (Bill of Rights) of the Const...
Community Development Vis-à-Vis Information Science and Technology (IST): A Perspective of Development Studies
Abstract: Development is an important term in most all perspective. There so many stakeholders, agencies, institutions are responsible, form community development. Information is treated as most powerful term for develop...
Recent Vapour-Liquid Condensation Phenomena Challenges in Annular Tube
Abstract:This paper presents a review of the recent challenges on vapour-liquid condensation phenomena inside the annular tube. The condensation phenomenon is a main concern in nuclear power plant safety system. The cond...
Analysis of the Company Image and Service Quality through Customer Satisfaction to Customer Loyalty(A Field Research in PT. Nusantara Water Centre)
Abstract:This study aimed to analyze the influence of company image and service quality on customer loyalty through customer satisfaction in the environment laboratory PT. Nusantara Water Centre Jakarta. Data research co...