Efficiency of Supplemental Vitamin D in Patients with Chronic Obstructive Pulmonary Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 16
Abstract
Aims: To investigate the impact of supplemental vitamin D on pulmonary function in patients with stable chronic obstructive pulmonary disease (COPD). Study Design: Case-control study Place and Duration of Study: Department internal medicine, Rouhani hospital, Babol university of medical sciences, Babol, Iran. Over six months from September 2011 through February 2012 Methodology: Patients with COPD allocated to the treatment or control group intermittently. Thirty patients in the treatment group received 50.000 IU oral cholecalciferol weekly for two months plus routine treatment and 28 patients who served as controls received only their usual medications. The serum 25-hydroxyvitamin D (25-OHD) and FEV1% was measured at baseline and two months later. The primary objective was to determine treatment response defined as 5% or greater increase from baseline in FEV1% and the secondary objective was to determine the association between vitamin D supplementation and treatment response. In statistical analysis Spearman's correlation coefficient was used to determine correlation and logistic regression analysis with calculation of odds ratio (OR) was used to determine association. Results: Mean age of the patients and controls was 67.1±10.5 years and 66.±12.2 years respectively (P=0.83).Thirteen patients (43.3%) versus 3 (10.7%) controls responded to treatment (P=0.009). Treatment response was positively correlated with mean serum 25-OHD changes from baseline (Spearman's correlation coefficient = 0.358, P=0.026). Mean 25-OHD change from baseline in the responders was significantly higher than in no responders (P = 0.031). Mean 25-OHD changes were positively correlated with FEV1% (P = 0.013).Vitamin D supplementation increased the treatment response by OR = 6.37 (95% CI, 1.57-25.8). After adjustment for inhaled bronchodilator, corticosteroid therapy, age, weight, smoking, ESR and CRP the odds of treatment response in vitamin D group increased to 17.1 (95%CI, 2.39-122, P= 0.005). Conclusion: The findings of this study indicate that, two months vitamin D supplement to the drug regimen of COPD confers small pulmonary function improvement as compared with controls and justify serum 25-OHD measurement in COPD. Raising serum 25-OHD to sufficient levels with longer duration of treatment may exert further benefits.
Authors and Affiliations
Behzad Heidari, Mahmoud Monadi, Masumeh Asgharpour, Alireza Firouzjahi, Karim Hajian Tilaki, Mohsen Monadi
Keywords
Related Articles
- EP ID EP349462
- DOI 10.9734/BJMMR/2014/8373
- Views 55
- Downloads 0
Prediction of Renal Injury Risk by Expressions of KIM-1 and NGAL in Type 2 Diabetic Nephropathy
Background: About 10 to 40% Type 2 diabetes (T2DM) and 30% Type 1 diabetes (T1DM) suffer from kidney failure increases huge financial burden for care for patients [1]. Patients with uncontrolled diabetes prone to end-sta...
Applications and Efficacy of Photodynamic Therapy in Periodontics: A Review Study
Aims: Periodontitis is a common cause of tooth loss in adults and is an anaerobic bacterial infection. Enzymes, endotoxins and other cytotoxic bacterial products result in tissue destruction and initiation of chronic inf...
Domitest-S: A Novel Dichoptic Technique to Assess Ocular Sensory Dominance in Children: A Population Study
Aims: To assess sensory ocular dominance of children by means of a novel psychophysical technique (Domitest-S). Study Design: population study. Place and Duration of Study: Department of Ophthalmology, The Gradenigo Hos...
Circulating Angiogenesis Factors in Patients with Non-Hodgkin’s Lymphoma
Aims: Non-Hodgkin’s lymphoma (NHL) is a heterogeneous group of hematological malignancies. Several angiogenic factors are important in NHL. The objective of this study was to determine plasma levels of various proangioge...
The Inductive Effect of Purified Streptococcal M-protein on Immunity against Streptococcus pyogenes in Rabbit Model
Aims: The study aimed to know the effects of the purified M-protein on immune system to produce protection against Streptococcus pyogenes in rabbits. Study Design: Case-control study. Place and Duration of Study: In this...