Electron Microscopic Findings in Patients with Glomerulonephritis in Sudan
Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 10
Abstract
Glomerulonephritis (GN) is a common cause of end stage renal disease (ESRD). Electron microscopic studies bestowed significantly to the understanding of the pathogenesis of the disease process in GN. Its value has been strongly confirmed in diagnosis of glomerular diseases. To establish the role of electron microscopy in the diagnosis of glomerular diseases, in order to introduce services and to improve the histopathological standards of diagnosis of renal disease. Different patterns of EM in the different types of glomerular diseases in 132 renal biopsies from patients with glomerular diseases were evaluated. These specimens were stained and examined under the light microscopy (LM) then compared by transmission electron microscopy (TEM) findings. The most frequent types of glomerular disease was minimal change disease (22.7%), followed by lupus nephritis (20.5%). LM failed to diagnose the minimal change disease and Alport’s syndrome. In this study EM was found necessary in diagnosis of 37 cases (28%), supportive in diagnosis of 17 cases (12.9%) and not required in 79 (59.8%) of cases. The current study supported what had been concluded in the previous studies; EM still has an integral role and necessary for diagnosis of certain glomerularpathies e.g. minimal change disease.
Authors and Affiliations
Elryah I. Ali, Ishraga A. Osman, Ezeldine K. Abdalhabib, Abdelbaset Mohamed Elasbali, Ziad H. Al- Onzi, Hussain Gadelkarim Ahmed
Keywords
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