Electroreduction of tacrolimus as immunosuppressant agent at hanging mercury drop electrode: application to determination in pharmaceutical formulation
Journal Title: Journal of Reports in Pharmaceutical Sciences - Year 2012, Vol 1, Issue 1
Abstract
The adsorptive behavior of the immunosuppressive agent tacrolimus was studied by cyclic and differential-pulse voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and two well-defined peak currents were obtained at -1353 and -1417 mV vs. SCE (saturated KCl) in borate buffer (pH 10.0) + 0.1 KCl solution. A voltammetric procedure was developed for the determination of tacrolimus using differential-pulse adsorptive stripping voltammetry (DPAdSV). The optimum working conditions for determination of the drug were established. The analysis of tacrolimus in pharmaceutical dosage forms was carried out satisfactorily.
Aqueous Extract of Lavandula Angustifolia Alter Protein Expression in Alzheimer Rats
Alzheimer’s disease (AD) is the most common form of dementia has become one of the most severe progressive socio-economical and medical burdens facing countries all over the world. The drugs are currently available jus...
Design, Formulation and Physicochemical Evaluation of Acetaminophen Effervescent Tablets
Background: The main objective of this study was to design, formulate and evaluate the physicochemical properties of 500 mg acetaminophen effervescent tablets, in order to accelerate its analgesic and antipyretic effects...
Direct determination of arsenic in potassium citrate tablet using graphite furnace atomic absorption spectrometry
In this study, a rapid and simple method based on graphite furnace atomic absorption spectrometry (GFAAS) is described for direct determination of arsenic in potassium citrate tablet samples. Pyrolytic graphite tubes wer...
Hepatoprotective Effects of Pentoxifylline against Acrolein- Induced Mitochondrial Dysfunction in Rat Liver
Acrolein (ACR) is I±, I² unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. The aim of this study was to investigate t...
Polyamines Improve Anti-Blood Lactate Accumulation in an Acidosis Rat Model
Background: Lactic acidosis (lactate accumulation and pH downfall) occurs in a number of clinical conditions and has deleterious effects on the patient’s survival. Sodium bicarbonate and tromethamine are administrated in...