Electroreduction of tacrolimus as immunosuppressant agent at hanging mercury drop electrode: application to determination in pharmaceutical formulation

Journal Title: Journal of Reports in Pharmaceutical Sciences - Year 2012, Vol 1, Issue 1

Abstract

The adsorptive behavior of the immunosuppressive agent tacrolimus was studied by cyclic and differential-pulse voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and two well-defined peak currents were obtained at -1353 and -1417 mV vs. SCE (saturated KCl) in borate buffer (pH 10.0) + 0.1 KCl solution. A voltammetric procedure was developed for the determination of tacrolimus using differential-pulse adsorptive stripping voltammetry (DPAdSV). The optimum working conditions for determination of the drug were established. The analysis of tacrolimus in pharmaceutical dosage forms was carried out satisfactorily.

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  • EP ID EP340343
  • DOI -
  • Views 48
  • Downloads 0

How To Cite

(2012). Electroreduction of tacrolimus as immunosuppressant agent at hanging mercury drop electrode: application to determination in pharmaceutical formulation. Journal of Reports in Pharmaceutical Sciences, 1(1), -. https://europub.co.uk./articles/-A-340343