Elevated Circulatory Concentrations of Proinflammatory Cytokines in Hypertensive Patients with or Without Diabetes Mellitus
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
A number of studies suggest the association between proinflammatory cytokines and inflammation/ endothelial dysfunction in patients with hypertension. In the present study we made an attempt to measure the levels of circulatory proinflammatory cytokines such as IL-6, IL-12, TNF and IL-4 in hypertensive patients with or without type 2 diabetes mellitus (T2DM). A total of 81 (M/F: 33/48) subjects with or without hypertension were enrolled for this study. Group 1 were normotensive, group 2 hypertensive and group 3 were hypertensive T2DM patients. Our study revealed significantly increased circulatory IL-1, IL-6, IL-12 and TNF levels in hypertensive subjects as compared to the healthy volunteers. However, there was no significant difference between hypertensive T2DM patients and other hypertensive subjects. This data suggests that the augmented levels of these proinflammatory cytokines is a common factor in the pathogenesis of both hypertension and hypertension associated with T2DM.
Authors and Affiliations
Dr. R. Inmozhi Sivakamasundari
Keywords
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