Emergence of drug resistance of Acinetobacter at tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
BACKGROUND & OBJECTIVE Acinetobacter, although saprophytic, the emergence and spread of Acinetobacter in hospital environment is a major area of concern. . It has been associated with a wide variety of illnesses in hospitalized patients, especially patients in the intensive care units. These infections are often difficult to treat, because of the widespread antibiotic resistance. This study is conducted to know the prevalence and drug resistant pattern of Acinetobacter in tertiary care hospital. MATERIAL & METHODS 950 isolates of Acinetobacter were obtained from various clinical samples, and subjected to identification by different biochemical tests and antibiotic susceptibility testing by disc diffusion testing by Kirby Baurer method. RESULT Out of 950 isolates of Acinetobacter, 82% were Acinetobacter. calcoaceticus baumannii complex remained 18% were other Acinetobacter spp. Acinetobacter isolates were resistant to important groups of antibiotics tested, including amikacin (50%), gentamycin (65%), tobramycin (38%), ceftriaxone (92%), ceftazidime (80%), cefepime (88%), ampicillin-sulbactum (44%), piperacillin-tazobactum (38%),ciprofloxacin (81%) levofloxacin(82%), imipenem (10%) and trimethoprim-sulfamethoxazole (65%), meropenem (15%), polymixin B (2.2%), colistin (2%). CONCLUSION Early detection of MDR Acinetobacter and infection control practices are the best defense against these organisms. Rational use of antimicrobials is an important aspect to delay the emergence of XDR and PDR Acinetobacter spp.
Authors and Affiliations
Jethwa DK
Keywords
Related Articles
- EP ID EP410907
- DOI -
- Views 110
- Downloads 0
Ulcer Protective Activities of Bark of Artocarpus Heterophyllus Lam
Artocarpus heterophyllus Lam commonly known as jack fruit widely distributed in north east India, West Bengal and south Karnataka. Artocarpus heterophyllus containing polyphenolic compound like flavonoids and tannins a...
Ethnobotanical and Ethnopharmacological survey on Leptadenia reticulate (Wight &Arn)
Leptadeniareticulata(Robert Wight & George Arnott Walker Arnott), ethnopharmacognostical and ethno pharmacological survey was done to know its medicinal and therapeutic uses. The herb used in traditional treatment for...
Phytochemical screening and antiemetic activity of Lepidagatis cristata root extract
Lepidagathis cristata root (Family: Acanthaceae) is an herb distributed in central and eastern peninsular India and used as bitter tonic in fevers and used in pneumonia, flu, mouth and lip infections. An earlier study w...
Phytochemical screening of Desmostachya bipinnata, Canthium dicoccum Sebestiania chaemelea
Plants contain various phytochemical constituents i.e. primary and secondary metabolites. Various secondary metabolites have proved their therapeutic activities due to their medicinal properties. So phytochemical screeni...
Screening of antioxidant action of hesperidin in high cholesterol diet model in Wistar albino rats
Background Oxidative stress causes of various diseases in human. The present study aimed to evaluate the antioxidant effect of hesperidin in high cholesterol rats. Aim To evaluate the antioxidant action of hesperidin...