Emergent of Colistin Resistant Enterobacteriaceae carrying the mcr-1 gene among clinical isolates from patients in an Argentine hospital: Clinical and microbiological aspects
Journal Title: Global Journal of Infectious Diseases and Clinical Research - Year 2018, Vol 4, Issue 1
Abstract
The recent emergence of multidrug-resistant (MDR) or extremely drug-resistant (XDR) Gram-negative bacteria has renewed interest in colistin (Polymyxins, a family of cationic polypeptide antibiotics) as a last-resort in the treatment of severe bacterial infections [1,2], despite being a drug with potential serious adverse events (mainly high risk of nephrotoxicity) [3,4]. Acquired resistance to polymyxins is generally associated with chromosomal mutations [5,6]. However, increasing use of this antibiotic in clinical and veterinary practice has led to the emergence of mobile colistin resistance genes, including mcr-1, which was first reported in Escherichia coli in 2015 in China [7], and mcr-2, identified in Escherichia coli in 2016 in Belgium [8]. Recently, three further plasmid mediated colistin resistance genes, mcr-3, mcr-4 and mcr-5, were identified, with Enterobacteriaceae being the predominant hosts (particularly Escherichia coli and Salmonella spp). Mcr-1 and mcr-2 are the most frequent variants found in human clinical isolates. [7-11].
Authors and Affiliations
J Nievas, D Torres, F Nicola, P Bonvehí, L Scocozza, W Alcalá, S Relloso
Keywords
Related Articles
- EP ID EP533710
- DOI 10.17352/2455-5363.000019
- Views 60
- Downloads 0
Human Trichinosis in rural area Mountainous Provinces in Vietnam in 2015-2016
Trichinellosis is an important food borne parasitic zoonosis caused by nematodes in the world. From 1967 to 2013, six outbreaks of trichinellosis have been documented in four mountainous provinces of North Vietnam. This...
PCR-Based Method for Rapid and Minimized Electrochemical Detection of mecA Gene of Methicillin-Resistant Staphylococcus aureus and Methicillin-Resistant Staphylococcus epidermis
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important pathogens that cause nosocomial infections. However, microbiological culture techniques take a few days to yield results; therefore, a simpl...
Arthroscopic treatment for Intraarticular knee infection in Hanoi Medical University Hospital
Objectives: 1) Describe the arthroscopic image of infected osteoarthritis of knee; 2) Evaluate the result of arthroscopic treatment for infected osteoarthritis of knee Patients and method: Retrospective study 33 patients...
Pivmecillinam Treatment of Community-Acquired Uncomplicated Pyelonephritis Based on Sparse Data
Background: Pivmecillinam has good pharmacokinetic properties for treatment of infections in the urinary tract, and the mecillinam resistance rate in Enterobacteriaceae is very low. In a European guideline pivmecillinam...
Emergent of Colistin Resistant Enterobacteriaceae carrying the mcr-1 gene among clinical isolates from patients in an Argentine hospital: Clinical and microbiological aspects
The recent emergence of multidrug-resistant (MDR) or extremely drug-resistant (XDR) Gram-negative bacteria has renewed interest in colistin (Polymyxins, a family of cationic polypeptide antibiotics) as a last-resort in t...