Empiric therapy with vancomycin in the neonatal intensive care unit: let's “get smart” globally!
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 5
Abstract
Coagulase-negative staphylococci (CoNS) remain the most common organisms causing late-onset bloodstream infections (BSIs) among preterm infants in the neonatal intensive care unit (NICU).1–4 Since the vast majority, if not all, of CoNS isolates are resistant to beta-lactam agents, including the penicillinase-resistant penicillins, vancomycin remains the drug of choice for proven infections. When CoNS emerged in the 1980s as the most frequently detected pathogen among preterm infants in the NICU,5 many neonatologists and pediatric infectious disease specialists, including one of the authors (PJS), recommended the empiric use of vancomycin along with an aminoglycoside for suspected late-onset sepsis. The basis for this approach conformed to the traditional infectious diseases dogma that one should cover the most common organisms as part of empiric therapy.
Authors and Affiliations
Pablo Sánchez
Keywords
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- EP ID EP512020
- DOI 10.1016/j.jped.2016.06.001
- Views 58
- Downloads 0
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