ENDOCRINOLOGICAL ROLE OF LEPTIN IN OBESITY AND ASTHMA
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: Role of leptin resistance in correlation between obesity and asthma. Methods: High-caloric diet was given for 8 weeks to induce obesity. Ovalbumin followed by aluminum hydroxide was given to induce asthma. The animal was treated with leptin analog (0.4 mg/kg, i.p. for 7 days) and leptin antagonist (3 mg/kg, p.o., for 7 days). Biochemical parameters such as serum leptin, ghrelin, and tumor necrosis factor alpha (TNF-α) and physical parameters such as tidal volume and airflow rate were estimated to confirm the state of asthma and obesity, respectively. Results: It was found that leptin and ghrelin were elevated in obese and obese asthmatic condition, responsible for leptin resistance. Treatment with leptin analog and leptin antagonist significantly increases and decreases serum leptin levels, respectively. There was no significant change in TNF-α and ghrelin level after leptin analog treatment. The result of respiratory parameters improved with leptin analog. From our study, we found beneficial role of leptin analog in obese asthmatic condition. Conclusion: Leptin is an alternative treatment approach to treat obese asthmatic condition.
Authors and Affiliations
ARUN K SONI, ANAND B PITHADIA, SHRIKALP S DESHPANDE, BHANUBHAI N SUHAGIA
Keywords
Related Articles
- EP ID EP608754
- DOI -
- Views 121
- Downloads 0
FABRICATION, CHARACTERIZATION, AND IN VITRO EVALUATION OF PEGYLATED GLYCERIDE LABRASOL® NANOSTRUCTURED LIPID CARRIER COMPOSITES OF METHOTREXATE: THE PATHWAY TO EFFECTIVE CANCER THERAPY
Objective: The objective of the current study is to optimize and evaluate the potential of polyethylene glycolylated (PEG) glyceride Labrasol® nanostructured lipid carrier (NLC) composites of methotrexate (MTX) to achiev...
STUDIES ON GLUCOSE-LOWERING EFFICACY OF THE ACACIA SUMA ROXB. ROOT
Objective: The objective of the study was to evaluate the glucose-lowering efficacy of the Acacia suma Roxb. (Family: Fabaceae) root extracts on Wister albino rats. Methods: A. suma roots were shade dried, powdered, and...
SOLID DISPERSION - A NOVEL APPROACH FOR BIOAVAILABILITY ENHANCEMENT OF POORLY WATER-SOLUBLE DRUGS IN SOLID ORAL DOSAGE FORMS
Enhancement of the bioavailability of poorly water-soluble drugs is a challenging task in drug development. Currently 40% of new chemical entities are discovered as poorly water-soluble drugs. Solid dispersion is one of...
IDENTIFICATION OF BACTERIA CAUSING NECROTIC PULP WITH 16S rRNA GENE POLYMERASE CHAIN REACTION AND ANTIBIOTIC RESISTANCE TESTING AT THE DENTAL HOSPITAL IN SEKELOA, BANDUNG, INDONESIA
Objective: This study aims to identify the bacteria that cause necrotic pulp in teeth of dental patients and test resistance of the bacteria found to antibiotics. Methods: Bacteria were taken with paper points that were...
COMPARISON IN BENEFITS OF HERBAL MOUTHWASHES WITH CHLORHEXIDINE MOUTHWASH: A REVIEW
Objective: To discuss the benefits of herbal mouthwashes with the standard chlorhexidine mouthwash. This review is conducted to explore the benefits of herbal mouthwashes.Methods: Many herbal extracts are now available a...