Endopthalmitis- Microbiological Profile at a Tertiary Eye Care Hospital in Hyderabad
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 12
Abstract
Abstract: This is a retrospective study aimed to identify the microbial etiology of infectious endophthalmitis cases and to determine the antibacterial susceptibilities of bacterial isolates at Sarojini Devi Eye hospital a tertiary care eye hospital. A total of 52 patients with clinically diagnosed infectious endophthalmitis were microbiological evaluated from Jan 2016 to April 2018. Aqueous and vitreous aspirates were aseptically collected and cultured for bacteria and fungus using standard microbiological techniques.The specimens were subjected to Gram-staining and KOH mount. By Kirby-Bauer disk diffusion method Antibiotic sensitivity was performed for the commonly used intravitreal and topical antibiotics Out of 52 patients studied, 35 (67.31%) had post traumatic endophthalmitis, 12 patients (23.08%) had postoperative endophthalmitis, postcorneal infective endophthalmitis was seen in 02 patients (3.85%) and 03 patients (5.76%) had endogenous endophthalmitis. Of the total 52 cases only 24 (46.15%) were culture positive and 28 (53.85%) were culture-negative endophthalmitis. Bacterial growth was seen in 16 cases (66.67%) and 08 cases (33.33%) had fungal growth. A bacterial predominance was observed among causative organisms of exogenous endophthalmitis with staphylococcus epidermidis species being the most common.In posttraumatic endophthalmitis, gram-positive bacteria were the predominant species, followed by gram-negative bacteria and fungi. The isolated organisms were gram-positive bacteria and candida in postoperative endopthalmitis .In Endogenous endophthalmitis, .gram-negative bacteria were the predominant species and gram-positive cocci were also isolated. However, in postcorneal infective endophthalmitis, all infections were fungal.The sensitivity pattern showed varied sensitivity to the antibiotics tested like - peptide antibiotic Vancomycin for Gram-positive coverage showing 100% sensitivity to gram positive organisms and Bacillus spp,and the recently developed third and fourth-generation fluoroquinolones, such as Levofloxacin and Moxifloxacin, with their enhanced activity against Gram-positive pathogens, and broad-spectrum activity covered most organisms(92%) commonly encountered in bacterial endophthalmitis. Good vitreous specimen collection and accurate culture techniques will increase the recovery rate of causative microorganisms and play a major role in treating the cases the results of this study has identified the microbial spectrum of infectious endophthalmitis and their antibiotic susceptibility.
Authors and Affiliations
Dr. P. Ganga Bhavani, Dr. B. M Shanker Venkatesh
Keywords
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