Endoscopic and Histopathologic Features in Patients of Portal Hypertensive Duodenopathy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 4
Abstract
Objective: The aim of study is to describe the frequency of PHD in portal hypertension patients and its various clinical, endoscopic and histopathologic features. Methods: Ninety four patients with cirrhosis and portal hypertention were studied. Two duodenal biopsies from first and second part were obtained during upper endoscopy and sent for histopathologic examination. Twenty five dyspeptic patients were taken as control. Results: Endoscopic changes in duodenum during upper GI endoscopy were seen in 52 patients out of 94 patient (55.3%). These changes include erythema, erosion, ulcer and telangiectasia. Extending duodenal lesions were significantly higher in decompensated than in compensated cirrhotic patients. Erythema was the commonest lesion. ED (endoscopic duodenopathy) was significantly higher in patients of severe gastropathy (60.7%) than mild gastropathy (26.6%). Endoscopic Duodenopathy (ED) bleed was seen in 7.4%. ED was not related to variceal size and variceal bleed. Histopathologic changes includes capillary congestion, edema, apoptosis, fibrous changes and inflammation. These Histopathologic changes were not statistically significant between patients with or without ED. Conclusion: Portal hypertensive duodenopathy is not related to variceal size or variceal bleeding but it is significantly higher in patient having severe gastropathy. Portal hypertensive duodenopathy can be a cause of overt or obscure bleeding. Histopathologic duodenopathy is more prevalent than endoscopic duodenopathy.
Authors and Affiliations
Dr Mamta Sharma
Keywords
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