Endothelium-dependent and independent effect of Guibourtia tessmannii (Caesalpiniaceae) on vascular contractility of rat
Journal Title: The Journal of Phytopharmacology - Year 2019, Vol 8, Issue 3
Abstract
The stem barks of Guibourtia tessmannii (Caesalpiniaceae) are used in traditional Gabonese medicine as antihypertensive remedies. In the present study, we investigated vasorelaxant properties effect of aqueous extract from G. tessmannii and fuller understanding these mechanisms of action in vitro. The activity of Guibourtia tessmannii was evaluated on isolated aorta rings of rat constricted with KCl (80 mM) and norepinephrine (10-4 M). Cumulative concentrations (1 mg/mL - 100 mg/ml) of G. tessmannii provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl (95.69 ± 0.6% and 91.34 ± 4.90%, respectively). The vasorelaxant effect induced by G. tessmannii on the aorta precontracted by KCl was significant decreased in presence of Nω-nitro-L-arginine methyl ester (11.30 ± 4.3 %, p<0.05), tétraéthylammonium (52.2 ± 9.20 %, p<0.01). Indomethacin and atropine modify the vasorelaxant effect of plant extract (57.13± 6.9 %, p<0.01 and 58.83± 5.9 %, p<0.01, respectively. These results suggest that the vasorelaxant action of G.tessmannii was mediated via the muscarinic receptors. The direct effect of G.tessmannii to be mediated by alpha-adrenergic receptors and potassium channels.
Authors and Affiliations
Koumba Madingou Noreen Orianna, Aworet Samseny Reine Raissa, Souza Alain, Saba-benedyo Traore Alfred
Keywords
Related Articles
- EP ID EP49929
- DOI https://search.crossref.org/?q=10.31254%2Fphyto.2019.8302
- Views 219
- Downloads 0
Phytochemical screening and antimicrobial activities of the stem bark of Allanblackia parviflora Chev. (Clusiaceae)
This study has successfully explored the photochemistry and antimicrobial properties of the methanolic, aqueous and pet ether stem bark extracts of Allanblackia parviflora (Chevalier) (Clusiaceae). The qualitative phyt...
Pharmacological potential of naturally occurring nonstarch polysaccharides (NSP)
Since ancient times, plants have been serving as a promising source of medicines and in recent times, extensive research has been made to isolate, characterize and screen a number of phytoconstituents/secondary plant m...
Influence of microwave assisted extraction on antioxidant and antiplasmodial activities of Trichilia roka extracts
Antiplasmodial and antioxidant activities of extracts derived from Trichilia roka (Chiov) (Meliaceae) root bark were determined respectively in vitro and using two methods as well as 1,1-diphenyl-2-picrylhydrazyl radica...
Emodin, isolated and characterized from an endophytic fungus Polyporales sp., induces apoptotic cell death in human lung cancer cells through the loss of mitochondrial membrane potential
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a Chinese herbal anthraquinone that exhibits numerous biological activities, such as antitumor, antibacterial, antiinflammatory, and immunosuppressive. From an endophy...
Fabrication, characterization and evaluation of hepatoprotective activity drug loaded flavono nanoparticle delivery system
The liver is the second largest organ is tied to almost all the bodily processes as it is responsible for filtration and biotransformation of all incoming chemicals and fluids. Liver diseases are mainly caused by toxic...