Enhanced pharmacokinetics of omeprazole when formulated as gastroretentive microspheres along with piperine
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2014, Vol 4, Issue 0
Abstract
Objective: To investigate the formulation of gastroretentive microspheres of omeprazole along with piperine and estimate the pharmacokinetic parameters in comparison with omeprazole alone. Methods: In our present investigation, gastroretentive microspheres of omeprazole were prepared with the inclusion of piperine. Pharmacokinetic parameters like Cmax, Tmax and area under curve were estimated by administering the prepared microspheres to rabbits and the results were compared with omeprazole alone. Results: There was a significant increase in area under curve from 3.441依1.093 mg·h/mL to 14.422 依0.708 mg·h/mL along with an increase in Cmax. Conclusions: This clearly shows the increased absorption and decreased metabolism of omeprazole when administered along with piperine as gastroretentive microspheres.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP230025
- DOI 10.1016/S2222-1808(14)60427-8
- Views 115
- Downloads 0
The Prevalence of Palmaris longus agenesis among the Ghanaian population
Objective: Background: Studies have documented the agenesis of Palmaris longus muscle in different populations but none has included the Ghanaian population. Methods: The study involved 226 subjects (130 females and 96 m...
The importance ofeosinophil, platelet and dendritic cell in asthma
Asthma is a syndrome of variable airflow obstruction. It is characterized pathologically by bronchial inflammation and remodeling changes. Eosinophil infiltrate in asthma and a relationship between the degree of eosinoph...
Appendicular perforation in dengue fever: our experience
Dengue viral infections have become one of major emerging infectious diseases in the tropics. Acute abdomen occurring in dengue viral infection is not uncommon. The spectrums of acute surgical emergencies which raise sus...
Serum cortisol in dengue and dengue hemorrhagic fever: is there any clinical implication?
Dengue is an important mosquito-borne viral infection. This infection can be seen in many tropical countries and caused many infectious cases annually. The biochemical profile change during infection is very interesting....
Phagodeterrence, larvicidal and oviposition deterrence activity of Tragia involucrata L. (Euphorbiaceae) root extractives against vector of lymphatic filariasis Culex quinquefasciatus (Diptera: Culicidae)
Objective: To evaluate phagodeterrence or biting deterrence, larvicidal and oviposition deterrence activity of Tragia involucrata (T. involucrata) root extractives against Culex quinquefasciatus (Cx. quinquefasciatus). M...