ENHANCEMENT OF DISSOLUTION PROPERTIES OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE USING SYLYSIA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The objective of present study was to enhance the dissolution rate of Carvedilol (CAR) by using Solid dispersion technique. Solid dispersions in water soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability of a range of hydrophobic drugs. The poor solubility of Carvedilol leads to poor dissolution and hence variation in bioavailability. Carvedilol (CAR) is a beta blocker drug. In the present investigation Solid dispersions (SD) were prepared by employing different grades of silica gel (Sylysia). They were prepared by Solvent evaporation and kneading methods in three different mass ratios 1:1, 1:2 and 1:3. Comparison of the methods was also investigated. Physicochemical characterisation of disperse systems was carried out using differential scanning calorimetry(DSC), fourier transform infrared spectroscopy(FTIR). Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release. The prepared Solid dispersions were also evaluated for precompression parameters like angle of repose, bulk & tapped density, drug content, Carr's index and Hausner's ratio. Improved dissolution was observed in 1:3 ratio disperse system of kneading method compared to solvent evaporation method. Physicochemical characterisation results suggested that CAR existed in amorphous form in all dispersion systems which show that dissolution can be enhanced.
Authors and Affiliations
A. Bharathi*, , M. CH. Phanindra , G. Priyanka , S. Roja
Keywords
Related Articles
- EP ID EP90294
- DOI -
- Views 227
- Downloads 0
IN VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS/FRACTIONS OF IXORA PAVETTA
Free radicals play an important role in the development of tissue damage and pathological events in living organism. There is a compelling evidence indicates that increased consumption of antioxidants from fruits and veg...
ROLE OF REGULATORY AFFAIRS IN A PHARMACEUTICAL INDUSTRY
Regulatory affairs (RA) professionals play critical roles in a pharmaceutical industry because it is concern about the healthcare product lifecycle, it provide strategic, tactical and operational direction and support fo...
FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING MICROBEADS OF SUMATRIPTAN
Sumatriptan is a potent and selective 5-hydroxytryptamine agonist. It is an effective agent in the treatment of acute migraine attack. Sumatriptan is rapidly but incompletely absorbed following oral administration and un...
COSTUS SPECIOSUS AS ALTERNATIVE SOURCE OF MEDICINE FOR TISSUE REPAIR, NEOPLASMIC, METABOLIC DISORDERS, ALONG WITH ITS ANTI-HELMINTHIC AND ANTIBACTERIAL ACTIVITY
ABSTRACT Costus speciosus is an important medicinal plant which can be used as alternative source of medicine for Diabetes, wound repair, against certain cancer cells and as antibacterial. The article reviews som...