ENHANCEMENT OF DISSOLUTION PROPERTIES OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE USING SYLYSIA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The objective of present study was to enhance the dissolution rate of Carvedilol (CAR) by using Solid dispersion technique. Solid dispersions in water soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability of a range of hydrophobic drugs. The poor solubility of Carvedilol leads to poor dissolution and hence variation in bioavailability. Carvedilol (CAR) is a beta blocker drug. In the present investigation Solid dispersions (SD) were prepared by employing different grades of silica gel (Sylysia). They were prepared by Solvent evaporation and kneading methods in three different mass ratios 1:1, 1:2 and 1:3. Comparison of the methods was also investigated. Physicochemical characterisation of disperse systems was carried out using differential scanning calorimetry(DSC), fourier transform infrared spectroscopy(FTIR). Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release. The prepared Solid dispersions were also evaluated for precompression parameters like angle of repose, bulk & tapped density, drug content, Carr's index and Hausner's ratio. Improved dissolution was observed in 1:3 ratio disperse system of kneading method compared to solvent evaporation method. Physicochemical characterisation results suggested that CAR existed in amorphous form in all dispersion systems which show that dissolution can be enhanced.
Authors and Affiliations
A. Bharathi*, , M. CH. Phanindra , G. Priyanka , S. Roja
Keywords
Related Articles
- EP ID EP90294
- DOI -
- Views 225
- Downloads 0
FORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS
The main aim of proposed work was to develop Ropinirole matrix tablets sustained release dosage form, Ropinirole is Parkinson’s disease the sustained release formulation is the drug delivery system that is designed to ac...
FLOATING DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW AND ITS POSSIBLE SCOPE
In our day to day life oral dosage forms are known to be superior because of its advantages. Furthermore new Oral sustained release dosage forms (SRDFs) have been developed; however, this approach has not been suitable f...
COSTUS SPECIOSUS AS ALTERNATIVE SOURCE OF MEDICINE FOR TISSUE REPAIR, NEOPLASMIC, METABOLIC DISORDERS, ALONG WITH ITS ANTI-HELMINTHIC AND ANTIBACTERIAL ACTIVITY
ABSTRACT Costus speciosus is an important medicinal plant which can be used as alternative source of medicine for Diabetes, wound repair, against certain cancer cells and as antibacterial. The article reviews som...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF AMLODIPINE BESYLATE
The aim of present work was to prepare mouth dissolving tablets of Amlodipine besylate, used commonly for the treatment angina pectoris, commonly known as angina, is chest pain due to ischemia of the heart muscle, genera...
AN UPDATED REVIEW ON ANTI-ARTHRITIC MEDICINAL PLANTS
Arthritis is a chronic, inflammatory, systemic autoimmune disease characterized by pain, swelling and stiffness. Allopathic medications have been prescribed to alleviate symptoms of this disease which results into associ...