Enhancement of dissolution rate of Rosuvastatin calcium by complexation with β-cyclodextrins
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 3
Abstract
Abstract:The objective of the study was to increase dissolution rate of Rosuvastatin calcium (RST), a poorly water soluble drug which is a 3-hydroxy3-methyl glutaryl CoA (HMG-CoA) reductase inhibitor, through inclusion complexation with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD). The phase solubility studies indicated that the solubility of RST was significantly increased in the presence of β-CD and in the presence of HP-β-CD and AL type curve was obtained. Apparent stability constant (Ks) was found to be 32.4 M-1 for β-CD and 39.4M-1 for HP-β-CD. The inclusion complexes in 1:1 molar ratio for RST and carriers were prepared by three different methods viz. kneading, solvent evaporation and microwave irradiation method. The prepared complexes were characterized using FTIR, differential scanning calorimetry (DSC) and Powder X-ray diffractometry. The FTIR spectra of the prepared complexes showed the characteristic peaks of RST indicates there is no compatibility problem of drug with carriers. The DSC and X-RD showed crystalline nature of the prepared complexes. The prepared complexes dissolution profile was compared with physical mixture and pure drug. All the prepared complexes showed improved dissolution rate. The inclusion complex prepared with HP-β-CD by Microwave irradiation method exhibited greatest enhancement of dissolution rate by three folds. Keywords:Rosuvastatin calcium, β-cyclodextrin, Hydroxypropyl-β-cyclodextrin and microwave irradiation method.
Authors and Affiliations
Tanuja B, Vasavisowndarya A, Vijayalakshmi . T, Saimounika A, VenkataRamana M, Ramarao N
Keywords
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