Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 6
Abstract
The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of Cur-DPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of Cur-DPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.
Authors and Affiliations
Liandong Hu, Yanjing Shi, Jian Heng Li, Na Gao, Jing Ji, Feng Niu, Queting Chen, Xiaoning Yang, Shaocheng Wang
Keywords
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- EP ID EP682299
- DOI 10.1208/s12249-014-0254-0
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