Epidemiology of hepatocellular carcinoma in sub-Saharan Africa
Journal Title: Annals of Hepatology - Year 2013, Vol 12, Issue 2
Abstract
Published incidences of hepatocellular carcinoma in the Black population of sub-Saharan Africa underestimate the true incidence of the tumor because of the many instances in which hepatocellular carcinoma is either not definitively diagnosed or is not recorded in a cancer registry. Despite this, it is manifestly evident that the tumor occurs commonly and is a major cause of cancer deaths in Black African peoples living in the sub-continent, particularly in those living in rural areas. 46,000 new cases of hepatocellular carcinoma have been recorded to be diagnosed in sub-Saharan Africa each year, and age-standardized incidences of the tumor as high as 41.2/100,000 persons/year have been documented. The highest incidence of hepatocelular carcinoma has been recorded in Mozambique. The tumor occurs at a young age in rural dwelling and, to a lesser extent, urban dwelling Black Africans. It is also more common in men than women, particularly in the younger patients. Cirrhosis co-exists with hepatocellular carcinoma in about 60% of patients and is equally common in the two sexes. The tumor is not only common in the Black African population, it also carries an especially grave prognosis, with about 93% of the patients dying within 12 months of the onset of symptoms. Caucasians living in the sub-continent have a low incidence of hepatocellular carcinoma and it occurs at an older age.
Authors and Affiliations
Michael Kew
Keywords
Related Articles
- EP ID EP78249
- DOI -
- Views 124
- Downloads 0
Hepatitis E virus serum antibodies and RNA prevalence in patients evaluated for heart and kidney transplantation
Background. Acute hepatitis E virus (HEV) infection in solid organ transplant recipients is rare, but cancause severe hepatic and extrahepatic complications. We sought to identify the pretransplant prevalenceof HEV infec...
Building a Spanish-Latin American network on drug induced liver injury: much to get from a joint collaborative initiative
Decreased serum total T3 level in hepatitis B and C related cirrhosis by severity of liver damage
Objective. Thyroid hormones profile in patients with hepatic cirrhosis due to chronic HBV and HCV infections was evaluated in order to find any relationship between thyroid hormones and severity of liver damage. Materia...
Association between hepatitis B virus and chronic kidney disease: a systematic review and meta-analysis
Background. Hepatitis B virus infection and chronic kidney disease are prevalent and remain a major public health problem worldwide. It remains unclear how infection with hepatitis B virus impacts on the development and...
Insulin resistance and steatosis in chronic hepatitis C
In chronic hepatitis C, insulin resistance (IR) and type 2 diabetes mellitus (DM) are more prevalent than in healthy controls or in chronic hepatitis B patients. HCV infection promotes IR mainly through increased TNF-a a...