Epigenetic Modification of Nociceptive Mediators: Implications for the Etiology of Neural Hypersensitivity (Part I)
Journal Title: Science Insights - Year 2015, Vol 12, Issue 1
Abstract
Many factors have been identified contributing to the pathogenesis of pain, whereas we still cannot conquer the pain based on these findings suggesting that further studies are needed and other more potent mediators should be investigated. Epigenetics, in contrast to genetics, refers to the functionally relevant modifications to the genome that do not cause changes in underlying DNA sequence. These kinds of changes in gene expression or cellular phenotype regarded as landmarks of epigenetics are regulated by different types of modifications including gene methylation, histone acetylation, phosphorylation, imprinting and reprogramming etc. We, in this part (Part I), will review the general epigenetic modifications on molecular mediators on biological processes as the preface of the second part of the whole article (Part II will be available in the June issue of the journal). This general understanding of the epigenetic modification on the modulating factors that influence individual differences from pain sensitivity and responsiveness to analgesics possesses crucial clinical implications.
Authors and Affiliations
Shiqin Xu
Keywords
Related Articles
- EP ID EP689583
- DOI 10.15354/si.15.re015
- Views 195
- Downloads 0
Sappho – A Great Poetess of Ancient Greece
BACKGROUND Sappho is an Ancient Greek poetess, whose poetry is well known in western literature and greatly impacts the development of Greek poetry. In the ancient world she was considered to be an equal footing with Hom...
A Development Perspective of Point-Based Computer Graphics
Every object has its characteristic shape, appearance and responses to physical interactions. Computer graphics center on those three components of an object to bring them onto the computer display. With the rapid develo...
Unending Greed: The Real Drive of Human Warfare
There must be rivalry if there is life. Humans prioritize animal slaughter, followed by inter- and intra-racial violence, and finally by war over country borders. Finally, war is a result of a concerted effort by a large...
Landscape Art in A Treatise on Garden Design and The Craft of Gardens: A Comparative Analysis
A Treatise on Garden Design is the earliest Japanese treatise on landscape art, while The Craft of Gardens is its earliest Chinese counterpart. The former was composed roughly 500 years before the latter. Both are highly...
Gut Microbiota: The Mastermind behind the Body’s Hidden Balance
The best manifestation of the effective functioning of numerous tissues and organs in the human body is the maintenance of biological homeostasis. The gut microbiota’s balance is a potentially irreplaceable intrinsic mec...