EPIGENETICS OF REPRODUCTION
Journal Title: Folia Pomeranae Universitatis Technologiae Stetinensis Agricultura Alimentaria Piscaria et Zootechnica - Year 2016, Vol 39, Issue 328
Abstract
Epigenetic research offers a significant opportunity to understand the role of environmental interactions on the genome and disease, while enabling modulation of these interactions in order to improve human health. Knowledge of both genetic and epigenetic changes is essential for identification of functional gametes and for fertility treatment. Future studies in both human and animal models may enable better understanding of the mechanisms underlying the relationship between altered DNA methylation in the sperm cell and infertility. It is currently unclear whether methylation defects found in the DNA of infertile sperm are primary or secondary defects. An understanding of what underlies DNA methylation disorders will be important for the development of successful fertility treatments. While epigenetic research will unquestionably expand our knowledge of general genetics, it is mainly valued for its innovative and comprehensive approach to molecular diagnostics and is directed towards clinical procedures.
Authors and Affiliations
Magdalena CZUBASZEK, Katarzyna ANDRASZEK, Dorota BANASZEWSKA
Keywords
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