Epithelial Mesenchymal Transition Markers in Breast Cancer
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2018, Vol 20, Issue 1
Abstract
Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It can be associated with increased aggressiveness, and invasive and metastatic potential in cancer. The aim of the study was to assess the occurrence of EMT in human breast tumors by evaluation of epithelial markers Ecadherin, α-catenin, γ-catenin and mesenchymal markers Ncadherin and fibronectin. These markers were evaluated by immunohistochemistry on paraffin embedded tumor tissue section of 100 patients with breast carcinoma. Among epithelial markers, loss of γ-catenin α-catenin and E-cadherin expression was noted in 83%, 70% and 46% of breast tumors, respectively. Loss of α-catenin expression was significantly higher in histologic grade III tumors, BR score 7 tumors with a trend of reduced disease free survival (DFS) and overall survival (OS). Among mesenchymal markers, gain of N-cadherin and fibronectin expression was noted in 87% and 24% of breast tumors, respectively. A trend of reduced OS was noted in N-cadherin and Fibronectin positive patients. Further, a significant positive correlation of PRL-3 with cytokeratin and N-cadherin and of Snail with Vimentin and N-cadherin was noted. In multivariate survival analysis apart from clinicopathological parameters, Vimentin expression emerged as a significant predictor of reduced DFS and OS. PRL-3 and Snail are found to be upstream regulators in triggering EMT in breast cancer and showed significant association with mesenchymal markers N-cadherin and vimentin. Vimentin can be used as a biomarker for predicting disease aggressiveness at diagnosis.
Authors and Affiliations
Nupur Patel, Prabhudas Patel, Hemangini Vora
Keywords
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