Epithelioid Angiosarcoma of the Adrenal Gland. Report of a Case and Review of the Literature
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 4
Abstract
Background: Primary mesenchymal neoplasms of the adrenal gland are rare, and a malignant one is an extraordinary finding. Angiosarcomas are uncommon neoplasms and account for less than 1% of sarcomas. Due to their rarity, they can easily be misdiagnosed, both by the clinician and the pathologist. Case report: We present a case of 55 year old man with primary epitheloid angiosarcoma of the right adrenal gland and a review of the literature in an attempt to better define the clinical and pathological features of these neoplasms and their biologic potential. Immunohistochemical analyses were performed using endothelial cell markers (CD31, CD34 and Factor VIII). The analyses showed focal positivity of tumor cells, especially CD31 and weak focal positivity for tumor cells of Cytokeratin 18. The review of the literature showed 32 cases described up-to-date. Conclusion: The present case emphasizes problems in differential diagnosis that arise from its epithelioid differentiation. We show review of the relevant literature which underlines the poor clinical outcome of adrenal angiosarcoma despite the adequate surgical treatment.
Authors and Affiliations
Sotir Stavridis| Medical Faculty Skopje, University Clinic of Urology, Skopje, Republic of Macedonia, Aleksandar Mickovski| Medical Faculty Skopje, University Clinic of Urology, Skopje, Republic of Macedonia, Vanja Filipovski| Medical Faculty Skopje, Institute of Pathology, Skopje, Republic of Macedonia, Sasho Banev| Onkomedika, Skopje, Republic of Macedonia, Sasho Dohcev| Medical Faculty Skopje, University Clinic of Urology, Skopje, Republic of Macedonia, Ljupcho Lekovski| Medical Faculty Skopje, University Clinic of Urology, Skopje, Republic of Macedonia
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- EP ID EP8774
- DOI 10.3889/MJMS.1857-5773.2010.0119
- Views 330
- Downloads 15
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