ER and PR Positive Locoregional Breast Cancer in Elderly Women: Comparison of Response of Letrozole Alone and Letrozole Plus Surgery
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Hormone sensitive breast cancer in elderly women with locoregional disease, treatment with Letrozole (aromatase inhibitors) is often recommended. Many a times these patients are subjected to surgery also. Aim of this study was to compare the response of Letrozole alone versus Letrozole followed by surgery in these patients. Material and Methods: Neoadjuvant hormone therapy treatment was given to 40 postmenopausal breast cancer patients in form of Letrozole, who were Estrogen receptor (ER) positive and progesterone receptor (PR) positive. After Letrozole therapy, eligible patients underwent surgery, and those who were not candidates for surgery continued on Letrozole therapy. We retrospectively analyzed disease free survival at three years, and response with impact of surgery on outcome. Results: Out of 22 patients who underwent adjuvant surgery after neoadjuvant letrozole therapy only 8 (36.3%) could be offered lumpectomy and rest had mastectomy. 18 patients continued on letrozole therapy alone. At completion of three years the surgery group patient showed 72.7% DFS whereas letrozole only group had 55.5% DFS. Conclusions: The present study, also, shows a high response rate and disease free survival in patients having adjuvant surgery to neoadjuvant letrozole therapy.
Authors and Affiliations
Ravi Byahut, Mithilesh Kumar
Keywords
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