Establishing use of Concurrent HDR-ICBT with EBRT for management of Stage II cervical cancer at a Regional Cancer Center
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Background: ABS (American Brachytherapy Society) necessitates use of BT (Brachytherapy) for successful completion of management of locally advanced cervical cancer. Multiple dose fractionation schedules are available but none is currently standardized. Objective: To analyze two different concurrent HDR-ICBT (Intracavitary BT) schedules, their disease response, acute and late toxicities. Materials and Methods: 50 cases of histologically proven stage II cervical cancer were randomized into two arms, Arm A and Arm B. Patients in both arms received 50 Gy (Gray) (2 Gy/ fraction, 25 fractions, Monday to Friday) of EBRT (External Beam Radiotherapy) to whole pelvis with weekly cisplatin (40 mg/m2 ) on every Sunday. Patients in Arm A received HDR-ICBT regime of 7.5 Gy/fraction for 3 fractions, in Arm B patients received 6 Gy/fraction for 4 fractions on every Saturday. Results: Median follow up period of study was 14 months (range 7 – 20 months). There is no significant difference in local control and late toxicities in both arms. Conclusion: Both regimes of concurrent HDR- ICBT were tolerated well and were safe to use. Results of disease response and toxicity profile were also similar in both regimes.
Authors and Affiliations
Dr Neeti Sharma
Keywords
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