Estimation of flavonoid, phenolic content and free radical scavenging activity of fresh unripe fruits of lantana camara linn (verbenaceae)
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
The Lantana camara Linn (verbenaceae) is available throughout world as a weed. The genus Lantana includes 2500 species worldwide and is known for its bioactive secondary metabolites and essential oils. It is used for the treatment of various disorders. The therapeutic effects of tannins and flavonoids can be largely attributed to their free radical scavenging property and it is responsible for many pharmacological activities. The present study is designed for the extraction of fresh unripe fruits using alcohol (cold, hot and micro wave techniques). The extracts were investigated for phytochemicals, total phenolic components, flavonoidal content and in-vitro free radical scavenging property (DPPH–RSA method). The preliminary phytochemical investigations revealed that presence of glycosides, alkaloids, carbohydrates, flavonoids, inuline, tannins (phenolic compounds). The total Phenolic content of alcoholic extracts (cold, hot and micro wave) showed the content values of 4.67±0.22% w/w, 6.92±0.41% w/w and 7.291±0.13%w/w and total flavonoids estimation of alcoholic extracts (cold, hot and micro wave methods) showed the content values of 5.12±0.08% w/w, 6.623±0.32%w/w and 7.458±0.24%w/w for Quercetin respectively. Further investigation were carried out for In-vitro free radical scavenging assay by calculating its % inhibition by means of IC50 values, all the extracts concentration has been adjusted to come under the linearity range and here many reference standards like Tannic acid, Quercetin, Ascorbic acid have been taken for the method suitability. The results revealed that fresh unripe fruits of this plant have free radical scavenging potential. Among these results alcoholic extract by micro wave technique has more yield and more potent than other extraction methods. In conclusion that the Lantana camara Linn. (Verbenaceae) fresh unripe fruits possesses the antioxidant substance which may be potential responsible for the treatment of tumors and rheumatism and other oxidative stress related diseases.
Authors and Affiliations
Vedavathi T
Keywords
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