Estimation of Proteinuria in Type 2 Diabetes Mellitus: Is Spot Urine Protein-Creatinine Ratio as Efficacious as 24 Hours Urinary Protein
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 12
Abstract
Introduction: Diabetic nephropathy is a leading cause of morbidity and mortality in patients with diabetes mellitus. This study aims to compare the efficacy of spot urine protein creatinine ratio (PCR) with 24 hours urinary protein and urinary dipstick analysis in detection of proteinuria in patients with type 2 diabetes mellitus. Material and methods: Cross sectional study involving 75 consecutive patients with type 2 diabetes mellitus. The relationship between spot urine PCR and 24 urine protein and the relationship between spot urine PCR and urine protein dipstick analysis was found out using Pearson’s correlation analysis. The sensitivity, specificity, positive predictive value, negative predictive value of spot urine PCR for detecting proteinuria at a cut off value of 0.2 was calculated. Results: 75 patients of type 2 Diabetes mellitus were included (56 males and 19 females). The mean spot PCR was 0.38+/- 0.57 and the mean 24 hour urinary protein was 84.85+/-43.54 mg/day. Good positive correlation between spot urine PCR and 24 hour urine protein (r= 0.805) was noted. The sensitivity of spot urine PCR at a cutoff value of 0.2 was 98.25% and specificity was 94.44%. The area under curve for urine PCR was 0.996 (95% Confidence interval:0.986-1, p<0.0001). Conclusion: The spot urine PCR is as reliable as 24 hour urine protein and more reliable than spot urine dipstick analysis in detecting proteinuria in patients with type 2 diabetes mellitus. Hence, spot urine PCR can be used as an alternative to 24 hour urine protein for estimating proteinuria.
Authors and Affiliations
Akshatha Savith, Kruthika G Prasad, Rama Mishra R
Keywords
Related Articles
- EP ID EP433227
- DOI -
- Views 138
- Downloads 0
Speciation and Antimicrobial Susceptibility of Coagulase Negative Staphylococci, Isolated from the Anterior Nares of Health Care Workers, in A Tertiary Care Hospital in South India, with Special Reference to Methicillin Resistance
Introduction: Coagulase negative staphylococci (CoNS) are identified as emerging pathogens causing nosocomial infections, with significant morbidity and mortality. Speciation of CoNS helps in the understanding of their s...
Assessment of Precipitating Factors and Treatment Modalities of the Patients Suffering from Diabetic Foot Ulcer
Introduction: Foot disorders such as ulceration, infection or gangrene one of the leading causes of hospitalization in patients with diabetes mellitus. This variability is likely due to genetic, behavioral, and environme...
Prevalence of Anaemia in Hookworm Infestation in Children of Slum Areas in and around Dhanbad
Introduction: Hook worm infection is the most common intestinal parasitic infection of Nematodes. The hook worm two major species that affected humans, Necator americanus and Ancylostoma duodenale, Necator americanus is...
Frontal Facial Morphological Changes related to Twin Block Appliance using Posteroanterior Cephalogram - A Prospective Comparative Study
Introduction: The class II malocclusion is one of the most common orthodontic problems and is seen in nearly 1/3rd of the population. Study was done to assess the treatment induced dentoskeletal cephalometric changes in...
Evaluation of Rol of Serum Uric Acid Levels in Cases of Essential Hypertension
Introduction: The etiological factors associated with hypertension is difficult to predict because hypertension results from a complex interaction of genes and environmental factors. Previous researches have already stud...