Estimation of reference intervals for liver function tests in apparently healthy population of Lucknow
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 12
Abstract
Introduction: Liver function tests do vary with various factors like race/ethnicity, environmental, life styles, metabolic, physiological changes with advancing age and gender. Clinicians need to know these variations in reference interval when considering the presence of liver disease. There is scarce data of reference interval of liver function tests in north Indian population which have drastically different food habits, life style, exposure to environmental conditions as compared to the population of Southern and Eastern India. Material and Methods: Apparently healthy medical and paramedical professionals and healthy volunteer donors coming to the blood bank were included in the study and studied for eight liver function parameters. Results: 1302 subjects were screened for the study.265 subjects were excluded as 73 were diabetics (fasting 126mg/dl), 190 subjects had fatty liver detected on ultrasound and 2 were Hepatitis B positive. 1037 subjects were included. The upper and lower limit of Reference Interval (RI)(observed Vs reported) for Direct Bilirubin (0.3-0.9Vs 0.3-1.3, SGPT(19-53.5 Vs 7-41), SGOT(16- 47.0 Vs 12-38), GGT(35-90 Vs 9-58), ALP(47.5-134.5 Vs 33-96)were different as compared to reported standard RI. The upper limit of GGT (64-92 vs 34- 68), SGPT (18-54 vs20- 52) and SGOT (16-48 vs17- 45.8) was greater in males than females. The upper limit of SGPT was higher in urban population than rural and ALP showed more wide variation in RI in rural than urban population. Conclusion: The reference interval for most liver function tests determined in this study were different from the reported reference interval in literature. Larger community based studies are needed for determining reference intervals of our population which will provide valuable guidance for clinical practice and decision making.
Authors and Affiliations
Nikhil Gupta, Ritu Karoli, Jalees Fatima, Prem Shanker Singh, Amit P Srivastava, GG Agarwal
Keywords
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