Estimation of Tramadol Hydrochloride in Bulk and Formulation by Second Order Derivative Area Under Curve UV-Spectrophotometric Methods
Journal Title: International Journal of Advances in Scientific Research - Year 2015, Vol 1, Issue 7
Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Tramadol Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 272-280nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Tramadol Hydrochloride using 2-10μg/ml (r²=0.9925) for second order Derivative Area under Curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Tramadol Hydrochloride in pharmaceutical formulations.
Authors and Affiliations
Rekha Kharat, Santosh Balaso Jadhav, Shivaji Shinde, Seemarani Pawar, Ashpak Tamboli
Keywords
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- EP ID EP334119
- DOI 10.7439/ijasr.v1i7.1989
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