Estradiol Down-Regulates Gene Expression of Angiotensin-II Receptor Type One in Ovariectomized Rats
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 8
Abstract
Both estrogen deficiency and activation of renin-angiotensin- aldosterone system (RAAS) are implicated in the development of cardiovascular diseases in postmenopausal women, therefore this study aimed to clarify the influence of estradiol (E2) on expression of angiotensin receptor type one (AT1R) in target tissues of ovariectomized rats and whether it can add to the antihypertensive effects of angiotensin receptor blockers (ARBs). Fifty adult female rats were equally divided into 5 groups: Control group, ovariectomized (OVX) group not receiving any treatment, OVX group treated with conjugated estrogen (premarin), OVX group treated with valsartan and OVX group treated with premarin and valsartan. Treatments started 4 weeks after ovariectomy and continued for 8 weeks. By the end of experiment serum levels of renin, angiotensin-II, aldosterone, Na+ and K+ were measured. Hearts, adrenal glands, and kidneys were removed to quantify the gene expression of AT1R. Ovariectomy resulted in a significant increase in serum concentrations of renin, angiotensin-II, aldosterone, Na+ and AT1R gene expression, as well as a significant decrease in K+ concentration compared to control group. These findings were improved in all groups received either estrogen and/or valsartan. The best results were achieved when both drugs were used together. In conclusion concomitant use of estrogen with ARBs may provide a more effective form of RAAS blockade than the monotherapy of either of them.
Authors and Affiliations
Hamed M. Osman, Hanan F. Al-Saeed, Amani M. El Amin Ali, Azza M. Zaki
Keywords
Related Articles
- EP ID EP449885
- DOI -
- Views 61
- Downloads 0
Otorhinolaryngology, Head and Neck Surgery Services in Khartoum State in Sudan 2015
Background: In Khartoum state, formal health services are heavily centralized. This is reflected by a specialist services coverage that is double the national ratio in Sudan, as is the case for other health services and...
Prevention of Transmission of Zika Virus at Point of Entries - Experience from International Airport, Mumbai
Introduction: Zika virus is a mosquito borne flavivirus. It is transmitted by the bite of the Aedes Aegypti mosquito. In July 2015 Brazil reported an association between Zika virus infection and Gullain-Barre syndrome. I...
Nicorandil Induced Oral Ulceration - A Case Report and Review of Literature
Nicorandil, an antianginal drug is being commonly used worldwide (except in United States) across the spectrum of the coronary artery disease. It has been recognised as a causative factor for oral ulceration. The aim of...
Comparison of Dexmedetomidine Infusion with Saline Placebo for Smooth Extubation in Hypertensive Patient for Major Surgery
Background: The objective of this study was to compare the effects of intravenous dexmedetomidine and saline placebo on recovery characteristics in hypertensive patients. Methods: In a double blinded trial, forty patie...
Estradiol Down-Regulates Gene Expression of Angiotensin-II Receptor Type One in Ovariectomized Rats
Both estrogen deficiency and activation of renin-angiotensin- aldosterone system (RAAS) are implicated in the development of cardiovascular diseases in postmenopausal women, therefore this study aimed to clarify the infl...