Estrogen Receptor α and β Status in Hypertensive Postmenopausal Women with Co-morbidities
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1
Abstract
Menopause is accompanied by decline in estrogen levels and a substantial rise in the incidence of hypertension in majority of women. Whether this decline is in accordance with estrogen receptor levels and associated comorbidities need to be elucidated. Hence estrogen receptor status was assessed among selected hypertensive postmenopausal women with co-morbidities. A total of 12 postmenopausal women were selected and categorised into normotensive postmenopausal women (group-1), hypertensive postmenopausal women (group-2) hypertensive postmenopausal women with diabetes (group-3) and hypertensive postmenopausal women with renal insufficiency (group-4). Levels of estrogen receptor α and estrogen receptor β were assessed in these groups of postmenopausal women. One way ANOVA was performed using SPSS16.0 statistical software. No significant difference was found in estrogen receptor α levels between the groups. However, estrogen receptor β levels were significantly elevated in hypertensive postmenopausal women with renal insufficiency (group-4). The expression of these receptors might depend on the availability of estradiol. ERβ levels were found to increase with co-morbid conditions
Authors and Affiliations
Salini A
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