Ethanol Extract of Irvingia gabonensis (Bush Mango) Seed Improves Renal and Hepatic Functions in Wistar Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
The effect of ethanol extract of Irvingia gabonensis seed on some renal and hepatic function biomarkers was studied in ten Wistar rats. The rats were randomly assigned into two groups of five rats each: Group 1 (Normal group) received normal rat feed and water; Group 2 (Treated group) received 250mg/kg body weight of ethanol extract of Irvingia gabonensis seed in addition to normal rat feed and water. Treatment lasted for twenty-one days and was done twice daily via oral gastric intubation. Blood samples were collected from each rat via cardiac puncture for analysis of hepatic and renal function biomarkers. Serum AST and total protein concentrations were significantly (p<0.05) increased and ALT and ALP concentrations significantly (p<0.05) decreased in the treated group compared with the normal group. Serum creatinine, Na+ , and K concentrations were not significantly different between the two groups but Ca2+ concentration increased significantly (p<0.05) in the treated group compared with the normal group. In conclusion, Irvingia gabonensis seed therefore has the potential to improve liver and kidney functions in Wistar rats and may serve as a source of calcium. Increased consumption of Irvingia gabonensis seed is encouraged.
Authors and Affiliations
Stella O. Bassey, Onot O. Ekpe, Augustine L. Udefa, Nsimah M. Essien, Mbeh U. Eteng
Keywords
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- EP ID EP395447
- DOI 10.9790/3008-1303054650
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