EUDRAGIT-BASED NANOSTRUCTURES: A POTENTIAL APPROACH FOR OCULAR DRUG DELIVERY
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2012, Vol 1, Issue 2
Abstract
Drug delivery in ocular therapeutics is a challenging problem and is a subject of interest to scientists working in the multidisciplinary areas pertaining to the eye. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and pathophysiological barriers prevailing in the eye. Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. The potential use of polymeric nanoparticles as drug carriers has led to the development of many different colloidal delivery vehicles. Indeed, the association of an active molecule to a nanocarrier allows the molecule to intimately interact with specific ocular structures, to overcome ocular barriers and to prolong its residence in the target tissue. This review discusses the physiochemical characterization, fabrication techniques, therapeutic significances, patented technology of Eudragit based nanoparticles and future possibility in the field of ocular drug delivery.
Authors and Affiliations
Himanshu Pandey| Dept. of Pharmaceutical Sciences, Faculty of Health & Medical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad- 211007, Uttar Pradesh, India, Upendra Kumar Sharma| Institute of Pharmacy, Bundelkhand University, Kanpur Road, Jhansi, Uttar Pradesh, India, Avinash C. Pandey| Nanotechnology Application Center, University of Allahabad, Allahabad- 211002, Uttar Pradesh, India
Keywords
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