Eukaryotic Signature Proteins
Journal Title: Journal of Proteomics and Genomics Research - Year 2012, Vol 1, Issue 1
Abstract
Eukaryotic Signature Proteins (ESPs) are proteins that delineate the eukaryotes from the archaea and bacteria. They have no recognisable homologues in any prokaryotic genome, but their homologues are present in all main branches of eukaryotes. ESPs are thus likely to have descended from ancient proteins that have existed since the first eukaryotic cell. The last dataset of ESPs was calculated more than a decade ago, thus with advances in technology and the rapid completion of many evolutionary important genomes, this dataset required recalculating. This study recalculated the Giardia lamblia ESP dataset and provides a procedure to calculate signature proteins beginning with any species. The G. lamblia ESP dataset contained a range of proteins including many associated with the membrane, cytoskeleton, nucleus and protein synthesis. ESP datasets have implications on current models of eukaryotic evolution, having high importance in phylogenetic analysis due to ESPs’ consistency and conservation in all eukaryotic species.
Authors and Affiliations
Jian Han, Lesley J. Collins
Keywords
Related Articles
- EP ID EP261022
- DOI 10.14302/issn.2326-0793.jpgr-12-101
- Views 108
- Downloads 0
Computational EPAS1 rSNP Analysis, Transcriptional Factor Binding Sites and High Altitude Sickness or Adaptation
Purpose The endothetal Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) gene which encodes hypoxia-inducible-factor-2 alpha (HIF2a) is a transcription factor that is involved in the response to hypoxia. EPAS1 has been found...
Proteome and Proteomics: from Single Protein to Whole Body
No Abstract
Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis
Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the...
Eukaryotic Signature Proteins
Eukaryotic Signature Proteins (ESPs) are proteins that delineate the eukaryotes from the archaea and bacteria. They have no recognisable homologues in any prokaryotic genome, but their homologues are present in all main...
Optimization and ZSPORE Analysis of Affinity Purification Coupled with Tandem Mass Spectrometry in Mammalian Cells
Defining protein-protein interactions is essential for understanding the mechanisms by which cells regulate basic functions, such as metabolism, transcription, and signal transduction. Affinity purification followed by t...