Evaluating the clinical applications of visual evoked potentials in patients presenting with visual dysfunctions - A retrospective study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 7
Abstract
Background: The clinical applicability of visual evoked potential (VEP) tests has been progressively extending in neuro-ophthalmological workups. The role in monitoring and follow-ups are emerging as even more useful applications. Aims and Objectives: The present study aimed to assess the clinical role of pattern-reversal VEP (PRVEPs) in visual disorders with presumptive optic nerve involvement. Materials and Methods: PRVEP records of 58 patients with unilateral/bilateral visual loss in a study period of 1½ year were retrospectively analyzed. P100 latencies and N75-P100 amplitudes were compared with those of 60 age and sex-matched controls. Variations beyond three standard deviations were applied to define significant abnormalities. PRVEP records obtained by follow-up in some conditions were also assessed. Results: Traumatic optic neuropathy (32.76%) was the most common condition confronted, with major PRVEP finding as absent waveforms/reduced amplitudes. Monitoring of VEP records revealed improvement in 50% of patients on corticosteroid therapy. Functional visual disorders constituted 27.6% with 93.75% of subjects confirmed by PRVEP. Ethambutol-induced toxic optic neuropathy (20.69%) was associated with significant P100 delay bilaterally, in the majority. Out of which, 50% showed improved PRVEP records after 1 month of cessation of drug. Multiple sclerosis and optic neuritis though rarer conditions (3.44% and 6.89%, respectively) exhibited characteristic electrophysiological findings which helped confirming the diagnosis. Diabetic optic neuropathy (3.4%) and some very rare conditions also constituted the referrals. Conclusion: VEPs provides sensitive adjuncts to diagnosis in various visual disorders and contributes as important monitoring tools for objectively assessing the recovery and ophthalmological status.
Authors and Affiliations
Sangeeta Gupta, Punita Garg, Gaurav Gupta
Keywords
Related Articles
- EP ID EP491504
- DOI 10.5455/njppp.2018.8.0309519032018
- Views 59
- Downloads 0
Waist-hip ratio and cardiac responses to exercise in young adults with parental history of coronary heart disease
Background: Coronary heart disease (CHD) has become a major health challenge in India in 21st century. Family history is a major risk factor for CHD which strongly predisposes to atherosclerotic process at a younger age....
A prospective study of antibiotic sensitivity profile of pathogens isolated from surgical site infection at major surgical departments at tertiary care hospital
Background: A number of studies have been carried out in India and worldwide reporting different incidence rates of surgical site infections (SSIs), various pathogens isolated, and their antibiotic sensitivity pattern. T...
A study on the effect of atorvastatin on the pharmacokinetic and antidepressant activity of fluoxetine
Background: Polypharmacy is of wide concern in drug interaction. It is the leading cause of adverse drug reaction, and consequently, increasing the possibility of hospitalization and escalating the cost of care. The inci...
Medical and social risk factors for cardiovascular disease among elderly and old people
Background: Ageing is a natural biological process, manifested in a gradual decrease in the adaptive capacity of the organism. The causes of social alienation among elderly people have a multifactorial nature. Stroke is...
A study on the prevalence of childhood obesity in private schools of Kurnool city population
Background: Excessive energy intake and reduced physical activity are worldwide accepted contributing factors for childhood obesity. Aims and Objectives: The objective of this study was to study the prevalence of childho...