Evaluating the Prognostic Significance of Bone Marrow Megakaryocyte Count in Patients with Idiopathic Thrombocytopenic Purpura
Journal Title: Iranian Journal of Blood and Cancer - Year 2012, Vol 4, Issue 3
Abstract
Background: Previous studies about the relationship between bone marrow megakaryocyte count and the chronicity of ITP has yielded paradoxical results. The aim of the present study was to investigate any relationship between the megakaryocyte count in the bone marrow and the chronicity of ITP. Materials and Methods: This study was performed to compare the primary bone marrow aspiration megakaryocyte count, obtained early upon the diagnosis of ITP, between chronic ITP (case) and acute ITP (control) groups among patients aged less than 15 years old, at Mofid Hospital, Tehran and Amir-Kabir Hospital, Arak. Data collected was analyzed using SPSS version 18. The project was approved by local Ethics committee and written informed consent was obtained from all parents. Results: Three hundred and seven patients with ITP including 212 patients with acute ITP (69.1 %) and 95 patients with chronic ITP (30.9 %) participated in the study. The bone marrow megakaryocyte count was increased in 263 patients (85.7 %), decreased in 7 patients (2.3 %), and normal in 37 patients (12.1%). Among 212 patients with acute ITP, the bone marrow megakaryocyte count was increased in 182 patients (85.8 %), decreased in 5 patients (2.4%), and normal in 25 patients (11.8 %). Among 95 patients with chronic ITP, the bone marrow megakaryocyte count was increased in 81 patients (85.3 %), decreased in 2 patients (2.1 %), and normal in 12 patients (12.6%). There was no statistically significant difference between two groups regarding the megakaryocyte count. Conclusion: Based on our findings it seems that the variant of bone marrow megakaryocyte count is not related to the chronicity among patients with ITP.
Authors and Affiliations
A. Eghbali, M. Arzaninan, R. Jadidi
Keywords
Related Articles
- EP ID EP368582
- DOI -
- Views 58
- Downloads 0
Leukemia Cutis in a Child with Acute Lymphoblastic Leukemia at Diagnosis and Relapse
This article has no abstract.
Bone Mineral Density in β Thalassemia Major and Intermedia, Correlation with Biochemical and Hormonal Profiles
Background: Expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. The aim of this study was to assess bone mineral density (BMD) in patien...
Effects of Recombinant Urate Oxidase (Rasburicase) and Allopurinol for Prophylaxis and Treatment of Hyperuricemia in Patients with Leukemia and Lymphoma
Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims to weigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare th...
Relation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision ma...
Effect of Pamidronate on Osteoporosis in Patients with β-Thalassemia Major
Background: β-thalassemia major is a hereditary life threatening anemia which requires regular blood transfusion. Clinical symptoms of the disease are growth retardation, pallor, jaundice and skeletal alternations. The v...