Evaluating the Protective Impact of Ginger Extract Against Ciprofloxacin-Induced Hepatotoxicity in Male Albino rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
In the present study, potential protective impact of ginger extract against ciprofloxacin (CPFX)- induced hepatotoxicity in male rats was investigated. Forty-two adult male albino rats were divided into seven groups: control, dimethyl sulphoxide (DMSO), ginger (200 mg/kg), CPFX20 (20 mg/kg), CPFX20 plus ginger, CPFX40 (40 mg/kg) and CPFX40 plus ginger. Both CPFX and ginger doses were orally given to rats for 10 consecutive days. At the end of the experiment, serum and liver samples were processed for biochemical assays. Obtained results exhibited that treatment of rats with CPFX produced marked increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gammaglutamyl transferase (GGT) and total bilirubin. Also, CPFX markedly increased hepatic contents of malondialdehyde (MDA), protein carbonyl (PC), hydrogen peroxide (H2O2) and nitric oxide (NO). Meanwhile, the drug induced depletion in the hepatic levels of antioxidant parameters including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-s-transferase (GST). In addition, CPFX induced apoptosis in the hepatic cells as indicated by increased level of p53 and caspase-3 accompanied with decreased level of Bcl-2. The deleterious effects of CPFX on all measured biochemical indices seemed to be dose-dependent. Concurrent treatment with ginger extract and CPFX in rats significantly mitigated the CPFX-induced oxidative stress and apoptosis, and greatly recovered the biomarkers of the hepatocellular injury. This study addressed, for the first time, that ginger extract may be useful in the protection against liver damage induced by CPFX. The hepatoprotective impact of ginger might be mediated primarily by its potent antioxidant activity and its ability to scavenge free radicals.
Authors and Affiliations
Faried A. E. Hemieda, Wafaa M. El- Kholy, Aysha S. Abdalmawla Masud
Keywords
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- EP ID EP445302
- DOI 10.9790/3008-1401022330.
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