Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 4
Abstract
The online version of this article (doi:10.1208/s12248-012-9395-9) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Yang Chen, Joseph P. Balthasar
Microcalorimetric Method to Assess Phagocytosis: Macrophage-Nanoparticle Interactions
The online version of this article (doi:10.1208/s12248-010-9240-y) contains supplementary material, which is available to authorized users.
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels
The family of multidomain proteins known as the synaptic associated proteins (SAPs) act as molecular scaffolds, playing an important role in the signaling and maintenance of several receptors and channels. The SAPs consi...
Statistical Power Calculations for Mixed Pharmacokinetic Study Designs Using a Population Approach
Simultaneous modelling of dense and sparse pharmacokinetic data is possible with a population approach. To determine the number of individuals required to detect the effect of a covariate, simulation-based power calculat...
Disposition of acetaminophen and indocyanine green in cystic fibrosis-knockout mice
Drug treatment poses a therapeutic challenge in cystic fibrosis (CF) because the disposition of a number of drugs is altered in CF. Enhanced clearance of acetaminophen (APAP) and indocyanine green (ICG) have previously b...
Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters
The online version of this article (doi:10.1208/s12248-010-9225-x) contains supplementary material, which is available to authorized users.